|Table of Contents|

Effect of intraoperative opioid dosage on postoperative survival of patients with glioma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 19
Page:
3640-3643
Research Field:
Publishing date:

Info

Title:
Effect of intraoperative opioid dosage on postoperative survival of patients with glioma
Author(s):
LIU Xuejiao; ZHANG Wenhui; LIN Shiyan; ZHAO Liuyuan; CHEN Rui; TENG Lei; DAI Junzhu; SHAO Hongxue; ZOU Huichao
Department of Pain,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China.
Keywords:
opioids; glioma; overall survival; relapse-free survival
PACS:
R739.41
DOI:
10.3969/j.issn.1672-4992.2023.19.020
Abstract:
Objective:To investigate the effect of intraoperative opioid dose on postoperative survival of patients with glioma.Methods:The clinical data of 165 patients with glioma who underwent tumor resection were analyzed retrospectively.Patients were divided into high-dose group and low-dose group according to the median intraoperative opioid dose(2.1 mg).Kaplan-Meier method was used to draw survival curve and Cox risk regression model was used to analyze the single and multiple factors affecting overall survival(OS) and relapse-free survival(RFS).The relationship in OS and RFS between high dose and low dose groups was analyzed.Results:Univariate Cox regression analysis found no difference in RFS(HR:1.082,95%CI:0.914~1.280,P=0.360) and OS(HR:1.099,95%CI:0.925~1.305,P=0.282) between the high-dose and low-dose groups.Multivariate Cox regression analysis found that intraoperative opioid dose was not correlated with RFS(HR:0.807,95%CI:0.537~1.212,P=0.301) or OS(HR:0.908,95%CI:0.599~1.378,P=0.650).Kaplan-Meier survival analysis showed no significant difference in RFS(P=0.525) and OS(P=0.332) between the high-dose and low-dose groups.Conclusion:There is no correlation between intraoperative opioid dose and relapse-free survival and overall survival in glioma patients.

References:

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Memo

Memo:
黑龙江省卫健委科研基金(编号：204-058)
Last Update: 2023-08-31