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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2023 19

Page:

3630-3634

Research Field:

Publishing date:

Info

Title:

Prognostic factors and relationship with MELF invasion in endometrioid adenocarcinoma patients with low grade

Author(s):

HUANG Xiangyan¹; WANG Fuqiang²; DUAN Qing¹; WANG Miaomiao¹; LI Xiufang¹

1.Department of Gynecological Oncology;2.Pathology Center,Anyang Cancer Hospital,Henan Anyang 455000,China.

Keywords:

endometrioid adenocarcinoma; prognosis; microcystic/elongating/fragmented invasion; lymph node metastasis; progression-free survival

PACS:

R737.33

DOI:

10.3969/j.issn.1672-4992.2023.19.018

Abstract:

Objective:To investigate the prognostic factors and relationship with microcystic,elongated,and fragmented(MELF) invasion in endometrioid adenocarcinoma patients with grade 1-2,to provide more evidence for clinical treatment planning and prognostic evaluation.Methods:266 endometrioid adenocarcinoma patients with grade 1-2 were retrospectively chosen in the period from January 2010 to June 2017.All patients were grouped according to presence or absence of MELF infiltration and included MELF group(40 cases) and non-MELF group(226 cases).The clinicopathological characteristics and follow-up survival data were compared between 2 groups.The risk of pelvic lymph node metastasis and independent influencing factors of 5-year progression-free survival were evaluated by multivariate analysis method,and the influence and predictive value of MELF infiltration on clinical prognosis were proportion of myometrium invasion more than half,the proportion of pelvic lymph node metastasis and the proportion of vascular tumor thrombus in MELF group were significantly higher than non-MELF group£¨P<0.05£©.The 5-year progression-free survival of MELF group was significantly lower than non-MELF group in overall population£¨P<0.05£©.The 5-year progression-free survival of non-MELF group was significantly higher than MELF group in FIGO stage ¢ñ and ¢ò population£¨P<0.05£©.There was no significant difference in 5-year progression-free survival between MELF group and non-MELF group in FIGO stage ¢ó population£¨P>0.05£©.Multivariate analysis of Logistic regression model showed that MELF infiltration was the independent risk factor of pelvic lymph node metastasis£¨P<0.05£©.Multivariate analysis of Cox proportional hazards regression model showed that MELF infiltration and vascular tumor thrombus were the independent risk factors of progression-free survival£¨P<0.05£©.ROC curve analysis showed that MELF infiltration had satisfactory efficacy in predicting the risk of pelvic lymph node metastasis and disease progression with AUC of 0.82(95%CI:0.70~0.90) and 0.84(95%CI:0.74~0.96),respectively.Conclusion:MELF infiltration was correlated with CA125 level, cervical interstitial invasion, uterine muscle invasion, pelvic lymph node metastasis and vascular cancer thrombus.Patients with MELF-infiltrated endometrioid adenocarcinoma are at higher risk for pelvic lymph node metastasis and disease progression.

References:

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