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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2023 19

Page:

3610-3615

Research Field:

Publishing date:

Info

Title:

Expression of RNA Helicase DDX21 in human liver cancer tissue and its relationship with prognosis

Author(s):

ZHANG Kaili; ZHANG Xin; YANG Baoshan

The First Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150001,China.

Keywords:

liver cancer; RNA Helicase DDX21; immunohistochemistry; survival analysis

PACS:

R735.7

DOI:

10.3969/j.issn.1672-4992.2023.19.014

Abstract:

Objective:To explore the expression of RNA Helicase DDX21 in normal liver tissue and liver cancer tissue,and investigate the relationship and significance in primary hepatocellular carcinoma(HCC).Methods:Immunohistochemical method was used to detect the expression of RNA Helicase DDX21protein in 86 cases of patients with liver cancer who underwent radical resection.Statistical analysis the correlation amongst of RNA Helicase DDX21 protein expression in normal liver tissue and liver cancer tissue,disease-free survival and overall survival were analyzed by Kaplan-Meier.Results:The expression of RNA Helicase DDX21 paracancer tissue in cytoplasm was significantly higher than that in liver cancer tissue(P<0.05).Kaplan-Meier analyses of disease-free survival time and overall survival time of endometrial cancer patients with paracancer tissue in cytoplasm of RNA Helicase DDX21 expression show that liver cancer patients with high expression of RNA Helicase DDX21 had significantly longer disease-free survival and overall survival than those with low expression of RNA Helicase DDX21(P<0.05).Multivariate Cox regression model show that tumor size and the expression of RNA Helicase DDX21 protein were closely related to the prognosis(P<0.05).Conclusion:RNA Helicase DDX21 may be a very valuable biomarker,which can be used to intrefere with the prognosis of patients with liver cancer.

References:

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Last Update: 2023-08-31