|Table of Contents|

The progress of application of cerium oxide nanomaterials in tumor therapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 18
Page:
3488-3492
Research Field:
Publishing date:

Info

Title:
The progress of application of cerium oxide nanomaterials in tumor therapy
Author(s):
YANG Min1ZHANG Xuelin2JIA Dexin1DING Meijuan1YU Yan1
1.Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150000,China;2.Harbin Institute of Technology,Heilongjiang Harbin 150000,China.
Keywords:
cerium oxide nanoparticlesactivity of mimetic enzymeradiotherapyimmunotherapychemodynamic therapyphotodynamic therapy
PACS:
R730.5
DOI:
10.3969/j.issn.1672-4992.2023.18.029
Abstract:
Cerium oxide nanoparticles (CeO2NPs) have nano-enzyme activity and have been widely used in tumor therapy due to their unique redox surface chemistry,high stability,and biocompatibility.The enzyme-like activities of CeO2NPs mainly include catalase (CAT),peroxidase (POD),and superoxide dismutase (SOD).On the one hand,the SOD-like and CAT-like mimetic enzymes of CeO2NPs exhibit antioxidant activity,which can protect normal cells from oxidative stress and improve the hypoxic microenvironment of tumors.On the other hand,the POD-like mimetic enzymes of CeO2NPs exhibit oxidative activity,which can effectively kill tumor cells.This review of CeO2NPs and their enzyme-like activities in radiotherapy,immunotherapy,photodynamic therapy (PDT),chemodynamic therapy (CDT) and its combination with chemotherapy,targeted and starving therapy (ST) is presented,and the challenges and obstacles they face and their insights are presented,aiming to play a role in promoting the application of nanomaterials in tumor.

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Memo

Memo:
National Natural Science Foundation of China(No.81572824);国家自然科学基金(编号:81572824);黑龙江区域医疗中心肺癌精准医学诊疗平台项目(编号:2112-230000-04005-3888351)
Last Update: 1900-01-01