|Table of Contents|

Using two sample Mendelian randomization method to explore the causal relationship between tea intake and the risk of bladder cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 18
Page:
3450-3454
Research Field:
Publishing date:

Info

Title:
Using two sample Mendelian randomization method to explore the causal relationship between tea intake and the risk of bladder cancer
Author(s):
CHAI Hongqiang1; PANG Lei2; WU Ming1; LI Fei1; SHAO Jinkai2
1.The Fifth Clinical Medical College of Shanxi Medical University,Shanxi Taiyuan 030012,China；2.Department of Urology,Shanxi Provincial People′s Hospital,Shanxi Taiyuan 030012,China.
Keywords:
Mendelian randomization; bladder cancer; causal inference; genome-wide association study (GWAS)
PACS:
R737.14
DOI:
10.3969/j.issn.1672-4992.2023.18.022
Abstract:
Objective:To assess the causal effect of tea intake on bladder cancer using the two-sample Mendelian randomization (2-sample-MR，2SMR) method.Methods:Based on the data from a large-scale tea intake genome-wide association study (GWAS) and the GWAS of bladder cancer,we investigated the causality between tea intake and bladder cancer using an inverse variance weighted (IVW) method,MR-Egger analysis and weighted median method.Finally,sensitivity analysis is conducted to evaluate the stability and reliability of the results.Results:Inverse variance weighted method (OR=0.999,95%CI:0.995～1.000,P=0.465 20）,MR-Egger analysis（OR=1.000,95%CI:0.984～1.017,P=0.945 25）,and weighted median method（OR=0.998,95%CI:0.993～1.003,P=0.497 28） showed no causal relationship between tea intake and bladder cancer (P＞0.05).Conclusion:This result of two-sample Mendelian randomization analysis reveals no casual effect between tea intake and bladder cancer.

References:

［1］ZHAO LG,LI ZY,FENG GS,et al.Tea drinking and risk of cancer incidence:a meta-analysis of prospective cohort studies and evidence evaluation ［J］.Advances in Nutrition,2021,12(2):402-412.
［2］HALASEH SA,HALASEH S,ALALI Y,et al.A review of the etiology and epidemiology of bladder cancer:all you need to know ［J］.Cureus,2022,14(7):e27330.
［3］XU C,ZENG XT,LIU TZ,et al.Fruits and vegetables intake and risk of bladder cancer:a PRISMA-compliant systematic review and dose-response meta-analysis of prospective cohort studies ［J］.Medicine (Baltimore),2015,94(17):e759.
［4］SING FM,YANG WS,GAO S,et al.Epidemiological studies of the association between tea drinking and primary liver cancer:a meta-analysis［J］.Eur J Cancer Prev,2011,20(3):157-165.
［5］XU XY,ZHAO CN,CAO SY,et al.Effects and mechanisms of tea for the prevention and management of cancers:an updated review ［J］.Critical Reviews in Food Science,2020,60(10):1693-1705.
［6］KHAN N,MUKHTAR H.Tea polyphenols in promotion of human health ［J］.Nutrients,2018,11(1):39-54.
［7］YANG CS,LAMBERT JD,JU J,et al.Tea and cancer prevention:molecular mechanisms and human relevance ［J］.Toxicol Appl Pharmacol,2007,224(3):265-273.
［8］WU SH,LI F,HUANG X,et al.The association of tea consumption with bladder cancer risk:a meta-analysis ［J］.Asia Pac J Clin Nutr,2013,22(1):128-137.
［9］PIERCE BL,AHSAN H,VANDERWEELE TJ.Power and instrument strength requirements for mendelian randomization studies using multiple genetic variants ［J］.Int J Epidemiol,2011,40(3):740-752.
［10］ZHENG J,BAIRD D,BORGES MC,et al.Recent developments in mendelian randomization studies ［J］.Curr Epidemiol Rep,2017,4(4):330-345.
［11］GRECO MFD,MINELLI C,SHEEHAN NA,et al.Detecting pleiotropy in mendelian randomisation studies with summary data and a continuous outcome ［J］.Stat Med,2015,34(21):2926-2940.
［12］BURGESS S,THOMPSON SG.Interpreting findings from mendelian randomization using the MR-Egger method ［J］.Eur J Epidemiol,2017,32(5):377-389.
［13］VERBANCK M,CHEN CY,NEALE B,et al.Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases ［J］.Nat Genet,2018,50(5):693-698.
［14］MIYATA Y,MATSUO T,ARAKI K,et al.Anticancer effects of green tea and the underlying molecular mechanisms in bladder cancer ［J］.Medicines (Basel),2018,5(3):87-104.
［15］HAYAKAWA S,OHISHI T,MIYOSHI N,et al.Anti-cancer effects of green tea pigallocatchin-3-gallate and coffee chlorogenic acid ［J］.Molecules,2020,25(19):4553-4574.
［16］葛华,丛聪，詹皓，等.茶多酚抑制肿瘤作用研究进展［J］.人民军医,2020,63(1):4. GE H,CONG C，ZHAN H,et al.Research progress in the anti-tumor effect of tea polyphenols ［J］.People's Military Surgeon,2020,63(1):4.
［17］VANESSA C,GARY G.A review of the health effects of green tea catechins in in vivo animal models ［J］.Journal of Nutrition,2004,12:3431S.
［18］ALMATROODI SA,ALMATROUDI A,KHAN AA,et al.Potential therapeutic targets of Epigallocatechin Gallate (EGCG),the most abundant catechin in green tea,and its role in the therapy of various types of cancer ［J］.Molecules,2020,25(14):3146.
［19］ROMANO A,MARTEL F.The role of EGCG in breast cancer prevention and therapy［J］.Mini Reviews in Medicinal Chemistry,2021,21(7):883-898.
［20］DAS A,BANIK NL,RAY SK.Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes ［J］.Cancer,2010,116(1):164-176.
［21］KWAK TW,PARK SB,KIM HJ,et al.Anticancer activities of epigallocatechin-3-gallate against cholangiocarcinoma cells ［J］.Onco Targets Ther,2017,10:137-144.
［22］JIAN WX,FANG SH,CHEN TK,et al.A novel role of HuR in-Epigallocatechin-3-gallate (EGCG) induces tumour cells apoptosis ［J］.J Cell Mol Med,2019,23(5):3767-3771.
［23］ZAN LL,CHEN QF,ZHANG L,et al.Epigallocatechin gallate (EGCG) suppresses growth and tumorigenicity in breast cancer cells by downregulation of miR-25［J］.Bioengineered,2019,10(1):374-382.
［24］CAO Y,LIU Q.Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasis ［J］.Advances in Cancer Research,2007,97:203-224.
［25］LAMBERT JD,ELIAS RJ.The antioxidant and pro-oxidant activities of green tea polyphenols:a role in cancer prevention ［J］.Arch Biochem Biophys,2010,501(1):65-72.
［26］HAYAKAWA S,SAITO K,MIYOSHI N,et al.Anti-cancer effects of green tea by either anti- or pro-oxidative mechanisms ［J］.Asian Pacific Organization For Cancer,2016,4:1649-1654
［27］SHIRAKAMI Y,SHIMIZU M.Possible mechanisms of green tea and its constituents against cancer ［J］.Molecules,2018,23(9):2284-2297.
［28］THOMPSON JR,MINELLI C,BOWDEN J,et al.Mendelian randomization incorporating uncertainty about pleiotropy ［J］.Statistics in Medicine,2017,36(29):4627-4645.
［29］BOWDEN J,SMITH GD,HAYCOCK PC,et al.Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator ［J］.Genetic Epidemiology,2016,40(4):304-314.

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