|Table of Contents|

Dosimetric comparison of different treatment plan optimization methods in Gamma Knife treatment of acoustic neuroma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 18
Page:
3447-3450
Research Field:
Publishing date:

Info

Title:
Dosimetric comparison of different treatment plan optimization methods in Gamma Knife treatment of acoustic neuroma
Author(s):
CAI Juntao; CHEN Jing; LI Peng; LI Yang; ZHANG Zhujun; XU Yunbo
Department of Neurosurgery,West China Hospital,Sichuan University,Sichuan Chengdu 610041,China.
Keywords:
acoustic neuroma; forward plan; inverse plan; dose
PACS:
R739.4
DOI:
10.3969/j.issn.1672-4992.2023.18.021
Abstract:
Objective:Dosimetric differences in acoustic neuroma target volume and organ at risk (OAR) were compared between manual forward plan(M-FP),manual shot inverse plan(MS-IP),automatic shot inverse plan(AS-IP).Methods:M-FP,MS-IP and AS-IP were redesigned respectively for twenty-six patients with acoustic neuroma.The target dose distribution,beam-on time(BOT) and OAR dose parameters were compared.Results:The coverage,selectivity and Paddick conformity index(PCI) of the two IP in the target dose distribution were better than those of M-FP,with a statistically significant difference (P＜0.05).There was no statistically significant difference between the two IP (P＞0.05).The gradient index (GI) of AS-IP was slightly higher than that of the other two plans.There was no significant difference between AS-IP and M-FP (P＞0.05),but there was significant difference between AS-IP and MS-IP (P＜0.05).The BOT of the three plans from high to low was M-FP,MS-IP,AS-IP,and the difference was statistically significant (P＜0.05).In terms of dose of OAR,Dmax and Dmean of cochlea in the two kinds of IP were lower than those of M-FP,the difference was statistically significant (P＜0.05),and there was no significant difference between two kinds of IP (P＞0.05).The Dmax,D0.1 cc and Dmean of brainstem of the three plans were not statistically significant (P＞0.05).Conclusion:The IP in the Leksell Gamma Knife GammaPlan may be a suboptimal plan during the optimization process,but compared to FP,the target dose distribution of IP is slightly better,providing better protection for small volume OAR,and demonstrating significant advantages in treatment time.If the optimization model is further improved in the future,it may have important significance for individualized treatment of clinical patients.

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