|Table of Contents|

FDXR and Nrf2 expression as predictive biomarkers for therapeutic response to chemoradiation in esophageal squamous cell carcinoma:A triple-center prospective clinical trial

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 18
Page:
3395-3399
Research Field:
Publishing date:

Info

Title:
FDXR and Nrf2 expression as predictive biomarkers for therapeutic response to chemoradiation in esophageal squamous cell carcinoma:A triple-center prospective clinical trial
Author(s):
LIU Hong12ZHAO Hongke3QIN Sheng4HOU Jun4LI Dan4LI Hua2ZHENG Maojia2CHEN Jing4
1.Chengdu BOE Hospital,Sichuan Chengdu 610000,China;2.Jiangyou Second People's Hospital,Sichuan Jiangyou 621071,China;3.The First Affiliated Hospital of Xinxiang Medical College,Henan Xinxiang 453100,China;4.Sichuan Cancer Hospital,Electronic Medical Sciences Affiliated Cancer Hospital,Sichuan Chengdu 610073,China.
Keywords:
predictive biomarkerFDXRNrf2esophageal carcinoma
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2023.18.011
Abstract:
Objective:To investigate the predictive value of FDXR and Nrf2 expression in chemoradiotherapy response of ESCC.Methods:A total of 150 patients with pathologically confirmed stage II-III ESCC from two cancer centers were included in this prospective study.FDXR and Nrf2 expression levels were assayed using immunohistochemistry.The FDXR and Nrf2 expression and the response to chemoradiotherapy were analyzed.Results:During the study,we collected 326 cases,of which 162 cases could be included in the final analysis.After concurrent chemoradiotherapy,the total response rate of 162 patients was 105,with a total response rate of 64.8%,a pCR rate of 28.5%,and a pathological partial response rate of 36.3%.The effective rate of FDXR positive patients was 42.6%,the effective rate of Nrf2 negative patients was 34.6,and the effective rate of FDXR positive patients combined with Nrf2 negative patients was 76.8%.In 162 cases,univariate analysis showed that tumor T stage,pathological grade,FDXR and Nrf2 affected the efficacy of radiotherapy and chemotherapy,while pathological grade,FDXR and Nrf2 were independent prognostic factors affecting the efficacy of radiotherapy and chemotherapy.Conclusion:Pathological grading of esophageal squamous cell carcinoma combined with FDXR and Nrf2 can effectively predict the sensitivity of radiotherapy and chemotherapy for esophageal carcinoma.

References:

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四川省卫生健康委员会科研课题(编号:17PJ597)
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