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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2023 17

Page:

3314-3318

Research Field:

Publishing date:

Info

Title:

Correlation and research progress of autophagy and chemotherapy resistance of tumor

Author(s):

LIU Mingdong; ZHU Jinhong

Department of Oncology,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China.

Keywords:

autophagy; chemotherapy; drug resistance; cancer

PACS:

R730.53

DOI:

10.3969/j.issn.1672-4992.2023.17.032

Abstract:

Autophagy is a self-degrading cellular process,which is mainly responsible for degrading dysfunctional or unnecessary proteins and organelles to maintain cell homeostasis.In recent years,the relationship between tumors and autophagy has been paid much attention.More and more evidences show that autophagy has a paradoxical role in tumor development and treatment.Chemotherapy is currently one of the most effective methods for the treatment of cancer,together with surgery and radiotherapy,it is called the three major treatment methods for cancer.However,the acquired drug resistance produced during chemotherapy has become the primary reason for tumor treatment failure.Studies have shown that autophagy is one of the key processes of tumor chemotherapy resistance.This article reviews the correlation and research progress of autophagy and tumor chemotherapy resistance.

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