«Previous Article|Table of Contents|Next Article»

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2023 17

Page:

3309-3314

Research Field:

Publishing date:

Info

Title:

Research progress on extracellular vesicles in pleural effusion as biomarkers for advanced non-small cell lung cancer

Author(s):

WANG Ding¹; CHE Chengri¹; CAI Jianhui²

1.The Affiliated Hospital of Yanbian University,Jilin Yanji 133000,China;2.Jilin Medical University,Jilin Jilin 132000,China.

Keywords:

extracellular vesicles; pleural effusion; advanced lung cancer; liquid biopsy; biomarker

PACS:

R730.231

DOI:

10.3969/j.issn.1672-4992.2023.17.031

Abstract:

Lung cancer is one of the most common malignant tumors worldwide,with approximately 80% being non-small cell lung cancer(NSCLC).Malignant pleural effusion,a common complication of advanced NSCLC,is closely related to patients' quality of life and prognosis.Extracellular vesicles(EVs) are nanoscale particles released by cells,containing components such as proteins,nucleic acids,and lipids,and are present in various bodily fluids including plasma,pleural effusion,and saliva.The study of tumor-associated EVs has opened up new avenues for understanding the mechanisms of tumor development and realizing the clinical application of EVs.In recent years,research has found that EVs in pleural effusion are ideal biomarkers for the diagnosis and treatment of advanced NSCLC.This review aims to summarize the current progress in the research of pleural effusion EVs as biomarkers for advanced NSCLC,highlighting their potential application value in NSCLC diagnosis,treatment and prognosis.

References:

£Û1£Ý BRAY F,FERLAY J,SOERJOMATARAM I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries£ÛJ£Ý.CA:a Cancer Journal for Clinicians,2018,68(6):394-424.
£Û2£Ý LI W,LIU J,HOU L,et al.Liquid biopsy in lung cancer:significance in diagnostics,prediction,and treatment monitoring£ÛJ£Ý.Molecular Cancer,2022,21(1):25.
£Û3£Ý SIEGEL R,MILLER K,JEMAL A.Cancer statistics,2018£ÛJ£Ý.CA:a Cancer Journal for Clinicians,2018,68(1):7-30.
£Û4£Ý TERRONES M,DE BEECK K,VAN CAMP G,et al.Pre-clinical modelling of ROS1+ non-small cell lung cancer£ÛJ£Ý.Lung Cancer(Amsterdam,Netherlands),2023,180:107192.
£Û5£Ý RECK M,RABE K.Precision diagnosis and treatment for advanced non-small-cell lung cancer£ÛJ£Ý.The New England Journal of Medicine,2017,377(9):849-861.
£Û6£Ý VARGAS A,HARRIS C.Biomarker development in the precision medicine era:lung cancer as a case study£ÛJ£Ý.Nature Reviews Cancer,2016,16(8):525-537.
£Û7£Ý SIRAVEGNA G,MARSONI S,SIENA S,et al.Integrating liquid biopsies into the management of cancer£ÛJ£Ý.Nature Reviews Clinical Oncology,2017,14(9):531-548.
£Û8£Ý THERY C,WITWER KW,AIKAWA E,et al.Minimal information for studies of extracellular vesicles 2018(MISEV2018):a position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines£ÛJ£Ý.J Extracell Vesicles,2018,7(1):1535750.
£Û9£Ý NAM G,CHOI Y,KIM G,et al.Emerging prospects of exosomes for cancer treatment:from conventional therapy to immunotherapy£ÛJ£Ý.Advanced Materials,2020,32(51):e2002440.
£Û10£Ý BECKER A,THAKUR BK,WEISS JM,et al.Extracellular vesicles in cancer:cell-to-cell mediators of metastasis£ÛJ£Ý.Cancer Cell,2016,30(6):836-848.
£Û11£Ý EGUCHI T,SHETA M,FUJII M,et al.Cancer extracellular vesicles,tumoroid models,and tumor microenvironment£ÛC£Ý.Seminars in Cancer Biology Elsevier BV,2022,86(1):112-126.
£Û12£Ý ISAAC R,REIS F,YING W,et al.Exosomes as mediators of intercellular crosstalk in metabolism£ÛJ£Ý.Cell Metabolism,2021,33(9):1744-1762.
£Û13£Ý XU R,RAI A,CHEN M,et al.Extracellular vesicles in cancer-implications for future improvements in cancer care£ÛJ£Ý.Nature Reviews Clinical Oncology,2018,15(10):617-638.
£Û14£Ý VIDAL M.Exosomes and GPI-anchored proteins:Judicious pairs for investigating biomarkers from body fluids£ÛJ£Ý.Adv Drug Deliv Rev,2020,161:110-123.
£Û15£Ý TEY SK,WONG SWK,CHAN JYT,et al.Patient pIgR-enriched extracellular vesicles drive cancer stemness,tumorigenesis and metastasis in hepatocellular carcinoma£ÛJ£Ý.Journal of Hepatology,2022,76(4):883-895.
£Û16£Ý CAVALLARO S,HAAG P,SAHU SS,et al.Multiplexed electrokinetic sensor for detection and therapy monitoring of extracellular vesicles from liquid biopsies of non-small-cell lung cancer patients£ÛJ£Ý.Biosens Bioelectron,2021,193:113568.
£Û17£Ý STILLER C,VIKTORSSON K,PAZ GOMERO E,et al.Detection of tumor-associated membrane receptors on extracellular vesicles from non-small cell lung cancer patients via immuno-PCR£ÛJ£Ý.Cancers(Basel),2021,13(4):922.
£Û18£Ý JAVADI J,G¦ZRGENS A,VANKY H,et al.Diagnostic and prognostic utility of the extracellular vesicles subpopulations present in pleural effusion£ÛJ£Ý.Biomolecules,2021,11(11):1606.
£Û19£Ý CAO B,DAI W,MA S,et al.An EV-associated gene signature correlates with hypoxic microenvironment and predicts recurrence in lung adenocarcinoma£ÛJ£Ý.Molecular Therapy Nucleic Acids,2019,17:879-890.
£Û20£Ý WANG Y,XU Y,ZOU Y,et al.Identification of differential expressed PE exosomal miRNA in lung adenocarcinoma,tuberculosis,and other benign lesions£ÛJ£Ý.Medicine,2017,96(44):e8361.
£Û21£Ý ROMAN-CANAL B,MOIOLA CP,GATIUS S,et al.EV-associated miRNAs from pleural lavage as potential diagnostic biomarkers in lung cancer£ÛJ£Ý.Sci Rep,2019,9(1):15057.
£Û22£Ý TAMIYA H,MITANI A,SAITO A,et al.Exosomal microRNA expression profiling in patients with lung adenocarcinoma-associated malignant pleural effusion£ÛJ£Ý.Anticancer Res,2018,38(12):6707-6714.
£Û23£Ý HYDBRING P,DE PETRIS L,ZHANG Y,et al.Exosomal RNA-profiling of pleural effusions identifies adenocarcinoma patients through elevated miR-200 and LCN2 expression£ÛJ£Ý.Lung Cancer,2018,124:45-52.
£Û24£ÝSHOJAEE S,ROMANO G,SANCHEZ TM,et al.Extracellular vesicle microRNA in malignant pleural effusion£ÛJ£Ý.Genes,2022,13(11):2159.
£Û25£Ý SONG Z,CAI Z,YAN J,et al.Liquid biopsies using pleural effusion-derived exosomal DNA in advanced lung adenocarcinoma£ÛJ£Ý.Transl Lung Cancer Res,2019,8(4):392-400.
£Û26£Ý QU X,LI Q,YANG J,et al.Double-stranded DNA in exosomes of malignant pleural effusions as a novel DNA source for EGFR mutation detection in lung adenocarcinoma£ÛJ£Ý.Front Oncol,2019,9:931.
£Û27£Ý LEE J,HUR J,KIM I,et al.Liquid biopsy using the supernatant of a pleural effusion for EGFR genotyping in pulmonary adenocarcinoma patients:a comparison between cell-free DNA and extracellular vesicle-derived DNA£ÛJ£Ý.BMC Cancer,2018,18(1):1236.
£Û28£Ý BANIJAMALI M,H¦ZJER P,NAGY A,et al.Characterizing single extracellular vesicles by droplet barcode sequencing for protein analysis£ÛJ£Ý.Journal of Extracellular Vesicles,2022,11(11):e12277.
£Û29£Ý BHATNAGAR R,MASKELL N.The modern diagnosis and management of pleural effusions£ÛJ£Ý.BMJ,2015,351:h4520.
£Û30£Ý FELLER-KOPMAN D,LIGHT R.Pleural disease£ÛJ£Ý.The New England Journal of Medicine,2018,378(8):740-751.
£Û31£Ý PORCEL J.Diagnosis and characterization of malignant effusions through pleural fluid cytological examination£ÛJ£Ý.Current Opinion in Pulmonary Medicine,2019,25(4):362-368.
£Û32£Ý HOSHINO A,KIM H,BOJMAR L,et al.Extracellular vesicle and particle biomarkers define multiple human cancers£ÛJ£Ý.Cell,2020,182(4):1044-1061 e18.
£Û33£Ý YU D,LI Y,WANG M,et al.Exosomes as a new frontier of cancer liquid biopsy£ÛJ£Ý.Molecular Cancer,2022,21(1):56.
£Û34£Ý GARCIA-MARTIN R,WANG G,BRANDAO BB,et al.MicroRNA sequence codes for small extracellular vesicle release and cellular retention£ÛJ£Ý.Nature,2022,601(7893):446-451.
£Û35£Ý TIN¦I M,BIONDINI D,DAMIN M,et al.Extracellular vesicles in lung cancer:bystanders or main characters£ÛJ£Ý.Biology,2023,12(2):246.
£Û36£Ý VANNI I,ALAMA A,GROSSI F,et al.Exosomes:a new horizon in lung cancer£ÛJ£Ý.Drug Discovery Today,2017,22(6):927-936.
£Û37£Ý LUO P,MAO K,XU J,et al.Metabolic characteristics of large and small extracellular vesicles from pleural effusion reveal biomarker candidates for the diagnosis of tuberculosis and malignancy£ÛJ£Ý.Journal of Extracellular Vesicles,2020,9(1):1790158.
£Û38£Ý SOROLLA MA,SOROLLA A,PARISI E,et al.Diving into the pleural fluid:liquid biopsy for metastatic malignant pleural effusions£ÛJ£Ý.Cancers(Basel),2021,13(11):2798.
£Û39£Ý WANG Y,LIU J,MA J,et al.Exosomal circRNAs:biogenesis,effect and application in human diseases£ÛJ£Ý.Mol Cancer,2019,18(1):116.
£Û40£Ý LIU Y,GU Y,HAN Y,et al.Tumor exosomal RNAs promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils£ÛJ£Ý.Cancer Cell,2016,30(2):243-256.
£Û41£Ý LIN LY,YANG L,ZENG Q,et al.Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer£ÛJ£Ý.Mol Cancer,2018,17(1):84.
£Û42£Ý GOODALL G,WICKRAMASINGHE V.RNA in cancer£ÛJ£Ý.Nature Reviews Cancer,2021,21(1):22-36.
£Û43£Ý TKACH M,TH¦IRY C.Communication by extracellular vesicles:where we are and where we need to go£ÛJ£Ý.Cell,2016,164(6):1226-1232.
£Û44£Ý SUN Z,SHI K,YANG S,et al.Effect of exosomal miRNA on cancer biology and clinical applications£ÛJ£Ý.Mol Cancer,2018,17(1):147.
£Û45£Ý WATABE S,KIKUCHI Y,MORITA S,et al.Clinicopathological significance of microRNA-21 in extracellular vesicles of pleural lavage fluid of lung adenocarcinoma and its functions inducing the mesothelial to mesenchymal transition£ÛJ£Ý.Cancer Med,2020,9(8):2879-2890.
£Û46£Ý PHAN T,TRAN B,NGUYEN S,et al.EGFR plasma mutation in prediction models for resistance with EGFR TKI and survival of non-small cell lung cancer£ÛJ£Ý.Clinical and Translational Medicine,2019,8(1):4.
£Û47£Ý ROBICHAUX J,LE X,VIJAYAN R,et al.Structure-based classification predicts drug response in EGFR-mutant NSCLC£ÛJ£Ý.Nature,2021,597(7878):732-737.
£Û48£Ý WAN J,MASSIE C,GARCIA-CORBACHO J,et al.Liquid biopsies come of age:towards implementation of circulating tumour DNA£ÛJ£Ý.Nature Reviews Cancer,2017,17(4):223-238.
£Û49£Ý WAN Y,LIU B,LEI H,et al.Nanoscale extracellular vesicle-derived DNA is superior to circulating cell-free DNA for mutation detection in early-stage non-small-cell lung cancer£ÛJ£Ý.Annals of Oncology,2018,29(12):2379-2383.
£Û50£Ý WAN Y,CHENG G,LIU X,et al.Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes£ÛJ£Ý.Nature Biomedical Engineering,2017,1(4):0058.
£Û51£Ý HUR J,KIM H,LEE J,et al.Extracellular vesicle-derived DNA for performing EGFR genotyping of NSCLC patients£ÛJ£Ý.Molecular Cancer,2018,17(1):15.
£Û52£Ý RODRIGUES G,HOSHINO A,KENIFIC CM,et al.Tumourexosomal CEMIP protein promotes cancer cell colonization in brain metastasis£ÛJ£Ý.Nat Cell Biol,2019,21(11):1403-1412.
£Û53£Ý HUANG C,HAYS FA,TOMASEK JJ,et al.Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle-mediated release of ezrin to inhibit tumour cell movement£ÛJ£Ý.J Extracell Vesicles,2020,9(1):1692417.
£Û54£Ý YANEZ-MO M,SILJANDER PR,ANDREU Z,et al.Biological properties of extracellular vesicles and their physiological functions£ÛJ£Ý.J Extracell Vesicles,2015,4(1):27066.
£Û55£Ý LI W,LI C,ZHOU T,et al.Role of exosomal proteins in cancer diagnosis£ÛJ£Ý.Molecular cancer,2017,16(1):145.
£Û56£Ý CABLE J,WITWER KW,COFFEY RJ,et al.Exosomes,microvesicles,and other extracellular vesicles-a Keystone Symposia report£ÛJ£Ý.Annals of the New York Academy of Sciences,2023,1:1-14.
£Û57£Ý DAASSI D,MAHONEY K,FREEMAN G.The importance of exosomal PDL1 in tumour immune evasion£ÛJ£Ý.Nature Reviews Immunology,2020,20(4):209-215.
£Û58£Ý CULLY M.Exosome-based candidates move into the clinic£ÛJ£Ý.Nat Rev Drug Discov,2021,20(1):6-7.
£Û59£Ý ZHANG S,CHEN L,ZONG Y,et al.Research progress of tumor-derived extracellular vesicles in the treatment of malignant pleural effusion£ÛJ£Ý.Cancer Medicine,2023,12(2):983-994.
£Û60£Ý ZHOU S,HU T,HAN G,et al.Accurate cancer diagnosis and stage monitoring enabled by comprehensive profiling of different types of exosomal biomarkers:surface proteins and miRNAs£ÛJ£Ý.Small,2020,16(48):e2004492.

Memo

Memo:

National Natural Science Foundation of China(No.21827812£©£»¹ú¼Ò×ÔÈ»¿Æѧ»ù½ðÖØ´ó¿ÆÑÐÒÇÆ÷ÑÐÖÆÏîÄ¿(±àºÅ£º21827812)

Common functions

Last Update: 2023-07-31