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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2023 17

Page:

3289-3295

Research Field:

Publishing date:

Info

Title:

Association analysis of non-high-density lipoprotein-cholesterol and TC/HDL-C ratio with cancer risk

Author(s):

XIE Yijing¹; JIANG Yonggen²; WU Yiling²; SU Xuyan²; ZHU Dongliang¹; WANG Jingru¹; GAO Peipei³; YUAN Huangbo³; ZHAO Qi¹; XU Kelin¹; ZHANG Tiejun¹; 4; 5; MAN Qiuhong⁶; CHEN Xingdong⁴; 5; 7; ZHAO Genming¹; JIANG Yanfeng³; 5; SUO Chen¹; 5; 8

Keywords:

lipid-related indexes; non-HDL-C; TC/HDL-C; cancer risk

PACS:

R730.1

DOI:

10.3969/j.issn.1672-4992.2023.17.027

Abstract:

Objective:Exploring the association between levels of non-HDL-C and TC/HDL-C ratio and cancer risk to assess the values in cancer prevention.Methods: The study was conducted on the general population cohort between April 2016 and November 2017 in several communities of Songjiang District.Permanent residents aged 20~74 years were recruited and they completed the questionnaires,physical examinations,and laboratory tests(blood and urine).Cox proportional hazard models and multivariable restricted cubic spline models were both used to assess the association and dose-response relationship of non-HDL-C and TC/HDL-C with cancer risk.Results:A total of 33 414 participants were involved,with a median follow-up year of 4.88,and 911 were newly diagnosed with cancer.There was an inverse association between non-HDL-C levels and cancer risk,and a 1-SD increment of non-HDL-C decreased cancer risk by 9%.Individuals with TC/HDL-C at 2.03~2.97 had an increased risk of cancer.Individuals with high non-HDL-C levels had a lower risk of developing cancer than those with low non-HDL-C levels was shown in males and the population without diabetes£ÛHR(95%CI)=0.74(0.56,0.99)£¬HR(95%CI)=0.79(0.64,0.98£©£Ý.Conclusion:non-HDL-C levels were associated with cancer risk,and it may be a potential modifiable risk factor of cancer.

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