|Table of Contents|

Detection of cognitive impairments after radiotherapy for patients with nasopharyngeal carcinoma using resting-state brain functional magnetic resonance imaging

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 17
Page:
3275-3279
Research Field:
Publishing date:

Info

Title:
Detection of cognitive impairments after radiotherapy for patients with nasopharyngeal carcinoma using resting-state brain functional magnetic resonance imaging
Author(s):
LIANG Chunyu1; XU Zhiyuan2; YANG Guohui1; WANG Wei1; LI Fei1; SHEN Xinping1
1.Department of Medical Imaging,Radiology Center；2.Department of Clinical Oncology,the University of Hong Kong-Shenzhen Hospital,Guangdong Shenzhen 518000,China.
Keywords:
nasopharyngeal carcinoma; radiotherapy; functional magnetic resonance imaging; resting state
PACS:
R739.6
DOI:
10.3969/j.issn.1672-4992.2023.17.024
Abstract:
Objective:To detection of cognitive impairments after radiotherapy for patients with nasopharyngeal carcinoma using resting-state brain functional magnetic resonance imaging.Methods:9 patients with nasopharyngeal carcinoma after radiotherapy and 9 patients with nasopharyngeal carcinoma before radiotherapy were scanned using resting-state brain functional magnetic resonance imaging，the differences of regional homogeneity(ReHo) and amplitude of low frequency fluctuation(ALFF) between the two groups were examined.Voxel based analysis was performed using two-sample t-test.Results:In patients with nasopharyngeal carcinoma after radiotherapy,decreased ReHo was deteted in left cerebelum and bilateral cerebellar peduncles.Also,decreased ALFF was found in the right middle frontal gyrus,bilateral inferior frontal gyrus.No increase in ReHo or ALFF was found in the brain area of patients with nasopharyngeal carcinoma after radiotherapy.Conclusion:Patients with nasopharyngeal carcinoma after radiotherapy show abnormal brain nerve activity at resting state,which may be related to cognitive dysfunction after radiotherapy.

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Memo

Memo:
广东省深圳市科学计划基础研究专项（自然科学基金）课题(编号：JCYJ20210324114600002)
Last Update: 2023-07-31