|Table of Contents|

Analysis of the incidence,severity and risk factors of potential drug interactions in hospitalized cancer patients

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 17
Page:
3270-3275
Research Field:
Publishing date:

Info

Title:
Analysis of the incidence,severity and risk factors of potential drug interactions in hospitalized cancer patients
Author(s):
GU Dawei1; LI Lu2
1.Department of Pharmacy,Hefei Cancer Hospital,Chinese Academy of Sciences,Anhui Hefei 230031,China;2.Department of Biochemistry,Department of Biological Sciences,College of Integrated Traditional Chinese and Western Medicine,Anhui University of Traditional Chinese Medicine，Anhui Hefei 230012,China.
Keywords:
cancer; hospitalized patient; potential drug-drug interactions; risk factors
PACS:
R246.5
DOI:
10.3969/j.issn.1672-4992.2023.17.023
Abstract:
Objective:To investigate the prevalence and severity of potential drug-drug interactions(pDDIs) in hospitalized cancer patients,and predict the associated risk factors.Methods:Extract medical orders from hospitalized tumor patients in our hospital from March 2022 to July 2022,and screen for potential drug interactions through IBM Micromedex.Results:137 of 282 patients had pDDIs,with an incidence of 48.58%.The main types of pDDIs were dexamethasone sodium phosphate and aprepitant,non-steroidal anti-inflammatory drugs and opioid analgesics,capecitabine and proton pump inhibitors.By multivariate Logistic regression analysis,age(≥60 years old),operation history,body mass index(BMI),polypharmacy(≥5 types),the length of stay in hospital(≥7 days) were the risk factors associated with pDDIs.Conclusion:The prevalence of pDDIs in hospitalized cancer patients is high，clinicians and pharmacists need to monitor and intervene the risk factors to improve the safety and rationality of drug treatment.

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Memo

Memo:
National Natural Science Foundation of China(No.81703826）；国家自然科学基金项目(编号：81703826);安徽省自然科学基金项目(编号：1808085MH301)
Last Update: 2023-07-31