|Table of Contents|

Clinical features and immune gene prognostic model construction of renal cell carcinoma with high expression of TFE3

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 17
Page:
3257-3265
Research Field:
Publishing date:

Info

Title:
Clinical features and immune gene prognostic model construction of renal cell carcinoma with high expression of TFE3
Author(s):
DOU QiongyiWANG XiangxuDENG ShizhouBAI YinmiaoZHANG Hongmei
Department of Clinical Oncology,Xijing Hospital,Air Force Medical University,Shaanxi Xi'an 710032,China.
Keywords:
TFE3renal cell carcinomaprognostic modelnomogram
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2023.17.021
Abstract:
Objective:The clinical and prognostic characteristics of 29 patients with TFE3-translocated renal cell carcinoma(RCC) were analyzed retrospectively.To comprehensively analyze the role of high TFE3 expression in the occurrence,development and prognosis of renal cell carcinoma based on the TCGA database by using a variety of bioinformatics methods.Methods:We retrospectively collected 29 patients with TFE3 translocation renal cell carcinoma treated in our hospital.Transcriptome data,mutation data and clinical data of renal cell carcinoma(KIRC and KIRP) were downloaded from the TCGA website.R software(4.1.0) was used for subsequent analysis.Results:The results showed that the prognosis of renal cell carcinoma with high TFE3 expression was worse than that of renal cell carcinoma with low TFE3 expression.TFE3 regulated the occurrence and development of renal cell carcinoma through PI3k-AKT-mTOR signaling pathway,and SETD2 mutation was higher in patients with high TFE3 expression in KIRP,which may make the patients have advantages in immunotherapy.We further constructed an prognostic model of renal cell carcinoma with high TFE3 expression and established a nomogram to predict the 1-,3-,and 5-year survival rates of patients.Conclusion:We investigated the underlying biological behavior behind high and low TFE3 expression in renal cell carcinoma and demonstrated that high TFE3 expression is an independent factor for poor prognosis in renal cell carcinoma.

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Memo

Memo:
陕西省自然科学基础研究计划重点项目(编号:2021ZJ-35)
Last Update: 2023-07-31