|Table of Contents|

Research status of CCL18 and its receptor in female malignant tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 16
Page:
3099-3105
Research Field:
Publishing date:

Info

Title:
Research status of CCL18 and its receptor in female malignant tumors
Author(s):
SUN BowenCHENG Yuan
Department of Obstetrics and Gynecology,Peking University People's Hospital,Beijing 100044,China.
Keywords:
CCL18receptorsignaling pathfemale malignant tumor
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2023.16.030
Abstract:
Chemokine CCL18 and its receptor play a very important role in the progression of female malignant tumors.In breast cancer,CCL18 mainly acts on the activation of downstream signaling pathway NF-κB and PI3K/Akt/GSK3β/Snail by PITPNM3 receptor,thus promotes tumor metastasis.CCL18 gene is highly expressed in cervical cancer and ovarian cancer,and can be used as a biomarker for diagnosis.CCL18 can also act on ERα receptors of endometrial carcinoma promote the epithelial-mesenchymal transformation of endometrial cancer cells.CCL18 and its receptors play a critical role in the progression of female malignant tumors,but the specific receptor and regulatory mechanism of CCL18 in endometrial cancer,cervical cancer and ovarian cancer are still unclear,which needs further study in the future.

References:

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Memo

Memo:
National Natural Science Foundation of China(No.82173119);国家自然科学基金资助项目(编号:82173119)
Last Update: 1900-01-01