|Table of Contents|

Characteristics and research progress of mitochondrial DNA mutations in tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 16
Page:
3093-3098
Research Field:
Publishing date:

Info

Title:
Characteristics and research progress of mitochondrial DNA mutations in tumors
Author(s):
SUN Tianlei1; ZHANG Yanfang2; GU Xiwen3; XING Jinliang3
1.College of Medical Technology,Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712000,China;2.College of Life Sciences,Northwest University，Shaanxi Xi'an 710000,China;3.College of Basic Medicine,Air Force Medical University,Shaanxi Xi'an 710032，China.
Keywords:
mitochondrial DNA; mutation; tumor heterogeneity; evolution
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2023.16.029
Abstract:
Mitochondrial DNA (mtDNA) mutations alter the function of mitochondria in oxidative metabolism and are one of the most common genetic events in tumors.With the rapid development of next generation sequencing technology,mtDNA sequencing data of tumors have increased dramatically,and mtDNA mutation characteristics of pancarcinomas have been revealed.Tumor heterogeneity has been widely reported in human tumors,and mtDNA mutations play an important role in tumor heterogeneity due to mitochondrial genome instability.In addition,evolutionary selection of mtDNA mutations also has an effect on tumor heterogeneity,and it is of great significance to elucidate complex evolutionary selection patterns for tumor research.In recent years,the genetic engineering technology directly targeting mtDNA has made progress,providing a means to accurately characterize the relationship between mtDNA mutations and tumor cell phenotypes.A thorough understanding of the characteristics of mtDNA mutations in tumors can provide new ideas for basic research and clinical diagnosis and treatment of tumors.

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Memo

Memo:
National Natural Science Foundation of China(No.81830070);国家自然科学基金资助项目(编号：81830070)
Last Update: 1900-01-01