|Table of Contents|

Relationship between hTERT gene polymorphism and the occurrence and development of cervical cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 16
Page:
3055-3060
Research Field:
Publishing date:

Info

Title:
Relationship between hTERT gene polymorphism and the occurrence and development of cervical cancer
Author(s):
WANG Yinghai; ZHANG Hongping; LI Chunlin; LU Yihan; LI Hang
Yunnan Cancer Hospital,Yunnan Kunming 650500,China.
Keywords:
cervical tumors; single nucleotide polymorphisms; telomerase reverse transcriptase
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2023.16.021
Abstract:
Objective:To explore the relationship between the known single nucleotide polymorphism of hTERT gene and cervical cancer,and look forward to finding the gene sites related to the occurrence and development of cervical cancer.Methods:A total of 100 patients with cervical malignant tumor diagnosed by pathology were selected as the experimental group,and 107 healthy women were classified as the control group.Nine hTERT gene SNP loci ［rs2853691 (C>T),rs2736122 (G>A),rs10069690 (C>T) in the DNA of cervical tumor specimens in the experimental group and peripheral blood specimens of healthy people in the control group were analyzed by TaqMan probe genotyping method.rs2853676 (C>T),rs2853677 (A>G),rs2075786 (A>G),rs2736098 (A>G),rs2853690 (A>G),rs2736114 (C>T)］ were genotyped.The relationship of alleles and genotypes with cervical cancer and related adverse prognostic factors was analyzed.Results:There was no statistical significance in allele frequency and genotype frequency of 9 SNP loci of hTERT gene between the experimental group and the control group.The hTERT rs2853677 (A>G) locus was dominated by AA (43.2%) genotype in highly differentiated cancer group and AG (66.7%) genotype in poorly differentiated cancer group,and the difference between the two groups was statistically significant (P=0.033).The genotype of hTERT s2736098 (A>G) was mainly AA (47.7%) in the highly differentiated cancer group,and AG (60.8%) in the poorly differentiated cancer group,and the difference between the two groups was statistically significant (P=0.042).There were no significant differences in alleles and genotype frequencies of other SNP loci among different stages of cervical cancer,pathological types and muscle infiltration groups (P＞0.05).Conclusion:Nine SNP loci of hTERT gene rs2853691 (C>T),rs2736122(G>A),rs10069690 (C>T),rs2853676 (C>T),rs2853677 (A>G),rs2075786 (A>G),rs2736098 (A>G),rs2853690 (A>G),rs2736114 (C>T) were not associated with the development of cervical cancer,but rs 2853677 (A>G),rs2736098 (A>G) A/G genotype may be associated with worse tissue differentiation of cervical cancer.

References:

［1］ MA A,EW B,LBC D,et al.Estimates of incidence and mortality of cervical cancer in 2018:a worldwide analysis-science direct［J］.Lancet Glob Health,2020,8(2):e191-e203.
［2］ ILIES R,HALMAGYI S,CATANA A,et al.hTERT role of rs2736100 in pathological scarring ［J］.Exp Ther Med,2022,23(4):260.
［3］ GUTMAJSTER E,CHUDEK J,AUGUSCIAK-DUMA A,et al.Possible association of the TERT promoter polymorphisms rs2735940,rs7712562 and rs2853669 with diabetes mellitus in obese elderly polish population:results from the national PolSenior study ［J］.J Appl Genet,2018,59(3):291-299.
［4］ KARISHMA KANHYA LAl,RABAIL JARWAR,SABAH FARHAT,et al.Association of Vaspin levels and its SNP rs2236242 with gestational diabetes at a tertiary care setting:Research article［J］.J Pak Med Assoc，2018,68(11):1736-1740.
［5］ MARRS C,CHESMORE K,MENON R,et al.Maternal human telomerase reverse transcriptase variants are associated with preterm labor and preterm premature rupture of membranes ［J］.PLoS One,2018,13(5):e0195963.
［6］ FENG L,NIAN SY,ZHANG JH.The GG genotype of telomerase reverse transcriptase at genetic locus rs2736100 is associated with human atherosclerosis risk in the Han Chinese population ［J］.PLoS One,2014,9(1):e85719.
［7］ DING Y,LI Q,WU C,et al.TERT gene polymorphisms are associated with chronic obstructive pulmonary disease risk in the Chinese Li population ［J］.Mol Genet Genomic Med,2019,7(8):e773.
［8］ REN G,LIU X,YU Z,et al.TERT association of polymorphisms with chronic hepatitis B in a Chinese Han population ［J］.Oncotarget,2018,9(10):9199-9205.
［9］ TRIFUNOVIC J,BASTA JOVANOVIC G,NIKOLIC N,et al.HTERT promoter methylation and single nucleotide polymorphism (-245 T>C) affect renal cell carcinoma behavior in Serbian population ［J］.J BUON,2018,23(6):1887-1892.
［10］ WALLENBORN M,XU LX,KIRSTEN H,et al.Molecular analyses of glioblastoma stem-like cells and glioblastoma tissue［J］.PLoS One,2020,15(7):e0234986.
［11］ YU Y,MAO L,CHENG Z,et al.A novel regQTL-SNP and the risk of lung cancer:a multi-dimensional study［J］.Arch Toxicol,2021,95(12):3815-3827.
［12］ LI Z,SONG Y,XU Y,et al.Identification of leukocyte telomere length-related genetic variants contributing to predisposition of esophageal squamous cell carcinoma ［J］.J Cancer,2020,11(17):5025-5031.
［13］ LILI M,YUXIANG F,ZHONGCHENG H,et al.Genetic variations associated with telomere length affect the risk of gastric carcinoma ［J］.Medicine (Baltimore),2020,99(23):e20551.
［14］ GAO C,ZHUANG J,ZHOU C,et al.SNP mutation-related genes in breast cancer for monitoring and prognosis of patients:A study based on the TCGA database［J］.Cancer Med,2019,8(5):2303-2312.
［15］ CIGAN S,MEREDITH J,KELLEY A,et al.Predicted leukocyte telomere length and risk of germ cell tumours ［J］.Br J Cancer,2022,127(2):301-312.
［16］ 李春琳,张红平,王应海,等.hTERT基因多态性与宫颈癌前病变关联性研究 ［J］.中华肿瘤防治杂志,2019,29(18):1323-1328. LI CL,ZHANG HP,WANG YH,et al.Relationship between hTERT gene polymorphism and cervical precancerous lesions ［J］.Chinese Journal of Cancer Prevention,2019,29(18):1323-1328.
［17］ TIAN J,WANG Y,DONG Y,et al.Cumulative evidence for relationships between multiple variants in the TERT and CLPTM1L region and risk of cancer and non-cancer disease ［J］.Front Oncol,2022,30(12):946039.
［18］ LIU Y,FAN PP,YANG YY,et al.Human papillomavirus and human telomerase RNA component gene in cervical cancer progression［J］.Sci Rep,2019,9(1):15926.
［19］ DOORSLAER KV,BURK RDJV.Association between hTERT activation by HPV E6 proteins and oncogenic risk ［J］.Virology.2012,433(1):216-219.
［20］ SHI Q,ZHANG XX,SHI XQ,et al.Identification of rs2736099 as a novel cis-regulatory variation for TERT and implications for tumorigenesis and cell proliferation［J］.J Cancer Res Clin Oncol,2022,21(9):1-8.
［21］ SHEN J,GAMMON M,TERRY MB,et al.Genetic polymorphisms in telomere pathway genes,telomere length,and breast cancer survival ［J］.Breast Cancer Res Treat,2012,134(1):393-400.
［22］ MICHELA DE MARTINO,CHRISTOPHER TAUS, ILARIA LUCCA，et al.Association of human telomerase reverse transcriptase gene polymorphisms,serum levels,and telomere length with renal cell carcinoma risk and pathology ［J］.Mol Carcinog,2016,55(10):1458-1466.
［23］ WANG S,WU J,HU L,et al.Common genetic variants in TERT contribute to risk of cervical cancer in a Chinese population ［J］.Mol Carcinog,2012,51(S1):E118-122.
［24］ ZHANG XY,CHEN Y,YAN DL,et al.TERT gene rs2736100 and rs2736098 polymorphisms are associated with increased cancer risk:A Meta-analysis.［J］.Biochem Genet,2022,60(1):241-266.

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