|Table of Contents|

Association between lactate receptor GPR81 expression levels and gefitinib acquired resistance in advanced lung adenocarcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 16
Page:
3028-3031
Research Field:
Publishing date:

Info

Title:
Association between lactate receptor GPR81 expression levels and gefitinib acquired resistance in advanced lung adenocarcinoma
Author(s):
ZHAO Mengmeng; KANG Xiaohong
Department of Radiotherapy,the First Affiliated Hospital of Xinxiang Medical University,Henan Xinxiang 453000,China.
Keywords:
GPR81; lung adenocarcinoma; gefitinib; acquired drug resistance
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2023.16.015
Abstract:
Objective:To observe the expression level of lactate receptor (GPR81) in advanced lung adenocarcinoma (LUAD) tissues,and analyze its correlation with clinicopathological parameters and gefitinib acquired resistance.Methods:The expression of GPR81 in the tissues of 65 LUAD patients was detected by immunohistochemistry,and the relationship between GPR81 expression and clinicopathological parameters of patients was analyzed by χ2.Radiographically,42 of the 65 LUAD patients were drug-resistant,and the expression level of GPR81 in the pathological tissues after drug resistance was detected by immunohistochemistry,and the relationship between it and gefitinib acquired resistance was analyzed by paired χ2 test.The relationship between GPR81 expression and patient progression-free survival (PFS) was analyzed by Kaplan-Meier survival analysis,and the relationship between multiple factors and patient PFS was analyzed by Cox model.Results:The expression level of GPR81 in tumor tissues of LUAD patients was positively correlated with lymph node metastasis and distant metastasis (P＜0.05).The expression level of GPR81 in tumor tissues after gefitinib resistance in 42 patients with LUAD was higher than that before treatment (P＜0.05).The results of Kaplan-Meier univariate analysis showed that the PFS of patients with high GPR81 expression was significantly lower than that of patients with low GPR81 expression (P＜0.05),and the results of multivariate analysis of Cox proportional hazard model showed that GPR81 expression level was a risk factor affecting the prognosis of patients with advanced LUAD.Conclusion:High expression of GPR81 is associated with lymph node metastasis,distant metastasis and PFS,indicating that it may promote the occurrence and development of LUAD.GPR81 was highly expressed in the tissues of patients with LUAD after gefitinib resistance,indicating that it was closely related to gefitinib targeted therapy resistance.

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Memo

Memo:
National Natural Science Foundation of China(No.82074231，81874392）；国家自然科学基金（编号：82074231，81874392）；河南省重点研发与推广项目（科技攻关）（编号：212102310209）；河南省海外英才研修项目（编号：HWYX2019085）
Last Update: 1900-01-01