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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2023 16

Page:

3018-3023

Research Field:

Publishing date:

Info

Title:

Association between polymorphisms in miR26a-1 rs7372209 and miR-612 rs12803915 loci and genetic susceptibility to lung cancer in Hainan

Author(s):

ZHOU Jing¹; KUANG Shicheng²; LI Yixuan¹; MENG Chong³; LIU Lirong³; LYU Pengfei⁴; ZHU Chaoyong⁵; HONG Yun¹; ZHANG Jing¹; CAO Wenting¹; XIAO Sha¹

Keywords:

miR26a-1; miR-612; single nucleotide polymorphisms; lung cancer; genetic susceptibility

PACS:

R734.2

DOI:

10.3969/j.issn.1672-4992.2023.16.013

Abstract:

Objective:To explore the association of polymorphisms in miR26a-1 (rs7372209,C>T) and miR-612 (rs12803915,G>A) and genetic susceptibility to lung cancer in people living in Hainan Province.Methods:A case-control study was applied.With the informed consent of the research subjects,a questionnaire survey was conducted and peripheral venous blood was collected to extract DNA.Genotypes were analyzed with a method of the SNaPShot.Statistical methods such as the chi-square test,Logistic regression analysis,were used to analyze the correlation between the polymorphisms of the two loci and the risk of lung cancer.Results:A total of 142 cases and 211 controls were recruited.The two groups were similar in terms of age,gender,and family history of tumor (P=0.258,0.143,0.688).The prevalence of smoking and drinking was significantly higher in cases than controls (P=0.002,0.023).After adjusting for confounding factors,the risk of lung cancer for the individuals with CT genotype and TT genotype at rs7372209 was much lower than CC genotype carriers (OR=0.58,95%CI=0.37~0.90,P=0.016),which was more pronounced in non-smoking(OR=0.50,95%CI=0.26~0.96,P=0.038),and non-drinking (OR=0.52,95%CI=0.31~0.86,P=0.011) subjects.Conclusion:In the miR26a-1 rs7372209 variant,T allele acts as a protective factor for the lung cancer in local people from Hainan,particularly in non-smokers and non-drinkers.

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Memo

Memo:

National Natural Science Foundation of China(No.81660550）；国家自然科学基金项目（编号：81660550）；海南省重点研发计划项目（社会发展）（编号：ZDYF2021SHFZ086）；海南省自然科学基金青年基金项目（编号：820QN268）；海南省卫生健康行业科研项目（编号：21A200032）

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