|Table of Contents|

Research progress of Th22 cells in the occurrence and development of hematological malignancies

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 15
Page:
2918-2922
Research Field:
Publishing date:

Info

Title:
Research progress of Th22 cells in the occurrence and development of hematological malignancies
Author(s):
GUO Sha1ZHANG Rui12QU Jianhua12
1.The First Affiliated Hospital of Xinjiang Medical University,Xinjiang Urumqi 830054,China;2.Institute of Hematology,Xinjiang Uygur Autonomous Region,Xinjiang Urumqi 830001,China.
Keywords:
Th22 cellsIL-22hematological malignancyleukemiamultiple myeloma
PACS:
R732
DOI:
10.3969/j.issn.1672-4992.2023.15.029
Abstract:
Helper T cells(Th) 22 cells are a newly discovered subset of helper T lymphocytes.Th22 cells mainly play a regulatory role in immune regulation,tissue repair and host defense through interleukin(IL)-22 as an effector factor.The key transcription factor of Th22 cells is aryl hydrocarbon receptor(AHR).New research shows that Th22 cells and cytokine IL-22 have certain significance in inflammation,autoimmune and allergic diseases and malignant tumors,and may become a potential target for the treatment of malignant tumors.This article reviews the research on Th22 cell subsets and its key cytokine IL-22 in hematological malignancies.

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Memo

Memo:
National Natural Science Foundation of China(No.8216010085);国家自然科学基金资助项目(编号:8216010085)
Last Update: 2023-06-30