|Table of Contents|

The value of revised Tokuhashi score in predicting the clinical prognosis of patients with spinal metastases and the choice of treatment methods

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 15
Page:
2910-2915
Research Field:
Publishing date:

Info

Title:
The value of revised Tokuhashi score in predicting the clinical prognosis of patients with spinal metastases and the choice of treatment methods
Author(s):
ZHANG Rui1; ZHANG Yihu2; ZHANG Yurong1; TONG Ling1; JIANG Xinting1; PENG Guolin1
1.Department of Orthopedics；2.Department of Emergency,the First Peoples' Hospital of Yibin,Sichuan Yibin 644000,China.
Keywords:
spinal metastasis; revised Tokuhashi scoring system; prognosis; prediction
PACS:
R738.1
DOI:
10.3969/j.issn.1672-4992.2023.15.027
Abstract:
Objective:To explore the value of revised Tokuhashi score in predicting the clinical prognosis of patients with spinal metastases and the choice of treatment methods.Methods:From January 2010 to December 2020,127 inpatients with spinal metastasis were reviewed from department of orthopedics in our hospital.The medical records were collected and the clinical outcomes were followed up until June 30,2022.The survival curve was drawn by Kaplan-Meier method.Log-rank Chi-square test and Cox regression analysis were used to analyze the factors affecting the prognosis of patients.Results:The median survival time of the patients was 10 months.The death rate in the follow-up period was 76.38%.The 6-month and 12-month survival rates were 69.29% and 27.56% respectively.The survival time of patients with revised Tokuhashi score of 0~8 points,9~11 points and ≥12 points was（6.99±2.54)months,(11.44±2.87)months and （18.56±4.80)months,respectively.The area under the ROC curve for predicting the prognosis of patients with revised Tokuhashi score was 0.960 and 0.863,respectively,without grouping and according to survival time ≤12 months.Cox regression showed that the revised Tokuhashi score,the number of extraspinal bone metastasis and visceral metastasis were the influencing factors of the prognosis of spinal metastasis.The HR of the revised Tokuhashi score of 9~11 points and ≥12 points were 0.484 and 0.033 respectively（compared with ≤8 points,P＜0.05),and the HR of the number of extraspinal metastasis of 1~2 sites and 0 site were 0.345 and 0.064 respectively（compared with ≥3 sites,P＜0.05).The HR of resectable visceral metastasis was 0.460（compared with inresectable visceral metastasis,P＜0.05).The 6-month survival rate of patients with revised Tokuhashi score of 0~8 points,9~11 points and ≥12 points was 45.45%,91.18% and 100.00% respectively.Conclusion:The prognosis of patients with spinal metastasis is poor.The revised Tokuhashi scoring system can predict the clinical outcome of patients,and has certain guiding significance for the rational selection of treatment methods.

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四川省卫计委科研课题（编号：18PJ572）
Last Update: 2023-06-30