|Table of Contents|

Research progress of OVOL family in cancer metastasis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 14
Page:
2738-2743
Research Field:
Publishing date:

Info

Title:
Research progress of OVOL family in cancer metastasis
Author(s):
TUO Dayun1LI Jinping1GAN Jinfeng23
1.Department of Histology and Embryology,Faculty of Basic Medical Sciences,Guilin Medical University,Guangxi Guilin 541199,China;2.Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation,Guilin Medical University,Guangxi Guilin 541199,China;3.Guangxi Health Commission Key Laboratory of Tumor Immunology and Receptor-Targeted Drug Basic Research,Guilin Medical University,Guangxi Guilin 541199,China.
Keywords:
OVOL familycancerEMTmetastasis
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2023.14.033
Abstract:
OVO-like proteins(OVOL) are a C2H2 zinc-finger transcription factor family that includes three members:OVOL1,OVOL2,and OVOL3.OVOL play an important role in embryonic development and can resist epithelial cells from an epithelial to a mesenchymal state.In recent years,an increasing number of studies have revealed that OVOL also play an important role in the progression of cancer.OVOL have been found to be dysregulated in various types of cancer including breast cancer,lung cancer,and colorectal cancer.OVOL can control cancer metastasis through the regulation of epithelial-to-mesenchymal transition(EMT).This review summarizes the role of OVOL in cancer metastasis as well as the mechanisms underlying their function.

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Memo

Memo:
National Natural Science Foundation of China(No.82160590);国家自然科学基金地区项目(编号:82160590)
Last Update: 1900-01-01