|Table of Contents|

Prognostic value of albumin to fibrinogen ratio in diffuse large B-cell lymphoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 14
Page:
2695-2699
Research Field:
Publishing date:

Info

Title:
Prognostic value of albumin to fibrinogen ratio in diffuse large B-cell lymphoma
Author(s):
SHI Xuebing1; WANG Lu2; DENG Wenxia1; WU Jing1
1.Department of Medical Oncology,Tongling People's Hospital,Anhui Tongling 244000,China;2.Department of Medical Oncology,Yijishan Hospital of Wannan Medical College,Anhui Wuhu 241000,China.
Keywords:
albumin; fibrinogen; diffuse large B-cell lymphoma; prognosis
PACS:
R733.4
DOI:
10.3969/j.issn.1672-4992.2023.14.023
Abstract:
Objective:To explore the effect of serum albumin(ALB) to plasma fibrinogen（FIB）ratio（AFR）on the prognosis of patients with diffuse large B-cell lymphoma（DLBCL）.Methods:Fifty nine cases of DLBCL diagnosed in our hospital from April 17th,2015 to March 18th,2022 were selected.The serum ALB and plasma FIB of all patients within 1 week before the first chemotherapy were collected to calculate the AFR.The impact of AFR on the progression free survival (PFS) of patients with DLBCL was evaluated by survival analysis.The area under the receiver operating characteristic (ROC) curve (AUC) was used to assess the capability of each model to predict the prognosis of DLBCL patients.Results:The range of AFR was from 3.87 to 20.13,with a median of 11.16.AFR was closely related to IPI,Ann Arbor staging,extranodal invasion and B symptoms.Kaplan-Meier survival analysis showed that the PFS of DLBCL patients increased significantly when AFR increased（P＜0.001）.Compared with low AFR group,the 2-year PFS of high AFR group increased by 73.0%.Cox univariate analysis showed that low AFR was a risk factor for PFS of DLBCL patients（P=0.002）.Multivariate analysis indicated that AFR was an independent factor affecting PFS of DLBCL patients（P=0.004）.The AUC values of international prognostic index (IPI) and IPI combined with AFR in predicting PFS of DLBCL patients were 0.778（95%CI 0.659～0.897,P＜0.001）and 0.829（95%CI 0.723～0.935,P＜0.001）respectively.Conclusion:AFR is an independent predictor of PFS in patients with DLBCL.IPI combined with AFR can better evaluate the prognosis of patients.

References:

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