|Table of Contents|

Value of preoperative mean platelet volume in predicting postoperative survival in elderly patients with esophageal squamous cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 14
Page:
2651-2655
Research Field:
Publishing date:

Info

Title:
Value of preoperative mean platelet volume in predicting postoperative survival in elderly patients with esophageal squamous cell carcinoma
Author(s):
ZHOU Shasha1; GUO Zhiyuan1; YANG Zhiyong1; YANG Chen1; YANG Yankuan2; WANG Yanwei3; ZHAO Bingfei1
1.Cancer Center,Handan Central Hospital,Hebei Handan 056001，China;2.Department of Oncology,Wei County People's Hospital,Hebei Handan 056800，China;3.Department of Pulmonary Medicine,the Sixth Hospital of Handan City,Hebei Handan 056001，China.
Keywords:
mean platelet volume; elderly patients; esophageal squamous cell carcinoma; survival
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2023.14.014
Abstract:
Objective:To investigate the value of preoperative mean platelet volume (MPV) in predicting postoperative survival of elderly patients with esophageal squamous cell carcinoma.Methods:259 elderly patients with esophageal squamous cell carcinoma who received surgical treatment in our hospital from January 2014 to December 2016 were included as study subjects.The ROC curve of preoperative MPV predicting the postoperative survival of elderly esophageal squamous cell carcinoma was drawn,and the best diagnostic cut-off point of preoperative MPV was obtained.All patients were divided into two groups according to the best diagnostic cut-off point of preoperative MPV.The propensity score of each patient was estimated by Logistic model,and the two patients with the most similar propensity score in the two groups were matched by 1∶1 propensity matching score (PSM),the balance of clinicopathological indexes of patients between the two groups were compared before and after matching.Kaplan Meier survival analysis was used to compared the postoperative disease-free survival rate and overall survival rate of elderly patients with esophageal squamous cell carcinoma between the two groups.Cox regression model was used for sensitivity analysis to verify the predictive value of matched preoperative MPV for postoperative survival of elderly esophageal squamous cell carcinoma.Results:The disease-free survival rate and overall survival rate of 259 elderly patients with esophageal squamous cell carcinoma were 60.3%,41.9%,25.1% and 86.1%,62.6% and 43.2% respectively.The ROC curve showed that the AUC of preoperative MVP predicting the postoperative survival of elderly patients with esophageal squamous cell carcinoma was 0.835(95%CI:0.776~0.897),and the best cut-off point for diagnosis was 12.7 fL.The corresponding sensitivity and specificity were 83.6% and 85.4% respectively.According to the optimal cut-off point of preoperative MPV,the patients were divided into 112 cases (43.2%) in the MPV≥12.7 fL group and 147 cases (56.8%) in the MPV<12.7 fL group respectively.The 1∶1 nearest neighbor PSM method was used.A total of 65 pairs of the two groups were successfully matched.After matching,there were no significant differences between the two groups in tumor diameter,pleural adhesion,TNM/T stage,lymph node metastasis,number of lymph node metastasis,and vascular tumor thrombus 6 indicators，the balance of the distribution of various indicators between the two groups was significantly improved (P>0.05).Kaplan Meier survival analysis showed that after matching,1-year,3-year and 5-year disease-free survival rate of patients in the MPV≥12.7 fL group was significantly lower in the MPV<12.7 fL group (51.6%,23.8%,18.5% vs 66.5%,48.8%,32.7%,χ2/P=5.789/0.024),and the 1-year,3-year,and 5-year overall survival rates of patients in the MPV≥12.7 fL group were significantly lower than those in the MPV<12.7 fL group (85.6%,51.8%,32.5% vs 92.5%,72.8%,51.7%,χ2/P=5.674/0.026).Cox regression analysis showed that for every 1 fL increase in preoperative MVP in elderly patients with esophageal squamous cell carcinoma,the risk of postoperative tumor recurrence and metastasis within 5 years increased by 0.895 times,and the risk of postoperative death within 5 years increased by 1.016 times.Conclusion:MPV as an evaluation index of activated platelets,can be used to evaluate the postoperative survival of elderly patients with esophageal squamous cell carcinoma,and has high predictive value.

References:

［1］乔友林.食管癌流行病学研究的重要里程碑［J］.中国肿瘤临床,2016,34(12):500-501. QIAO YL.An important milestone in the epidemiological study of esophageal cancer ［J］.Chinese Journal of Clinical Oncology,2016,34(12):500-501.
［2］袁勇,陈龙奇.AJCC第八版食管癌分期系统更新解读［J］.中华外科杂志,2017,55(2):109-113. YUAN Y,CHEN LQ.AJCC 8th Edition updated interpretation of esophageal cancer staging system ［J］.Chinese Journal of Surgery,2017,55(2):109-113.
［3］ALVES AM,DIEL LF,LAMERS ML.Macrophages and prognosis of oral squamous cell carcinoma:A systematic review［J］.J Oral Pathol Med,2018,47(5):460-467.
［4］HUSSEIN AA,HELDER MN,DE VISSCHER JG,et al.Global incidence of oral and oropharynx cancer in patients younger than 45 years versus older patients:A systematic review［J］.Eur J Cancer,2017 82(6):115-127.
［5］SONG GM,TIAN X,LIU XL,et al.Concurrent chemo-radiotherapy with S-1 as an alternative therapy for elderly Chinese patients with non-metastatic esophageal squamous cancer:evidence based on a systematic review and meta-analysis［J］.Oncotarget,2017,8(23):37963-37973.
［6］ISHIBASHI Y,TSUJIMOTO H,SUGASAWA H,et al.Prognostic value of platelet-related measures for overall survival in esophageal squamous cell carcinoma:A systematic review and meta-analysis［J］.Crit Rev Oncol Hematol,2021,164(8):103427.
［7］ZHANG F,WANG Y,WANG ZQ,et al.Efficacy and safety of cisplatin-based versus nedaplatin-based regimens for the treatment of metastatic/recurrent and advanced esophageal squamous cell carcinoma:a systematic review and meta-analysis［J］.Dis Esophagus,2017,30(2):1-8.
［8］KAO SS,OOI EH.Survival outcomes following salvage surgery for oropharyngeal squamous cell carcinoma:systematic review［J］.J Laryngol Otol,2018,132(4):299-313.
［9］FENG JF,SHENG C,ZHAO Q,et al.Prognostic value of mean platelet volume/platelet count ratio in patients with resectable esophageal squamous cell carcinoma:a retrospective study［J］.PeerJ,2019,7(6):e7246.
［10］YANG Y,ZHOU J,WU H.Diagnostic value of sentinel lymph node biopsy for cT1/T2N0 tongue squamous cell carcinoma:a meta-analysis［J］.Eur Arch Otorhinolaryngol,2017,274(11):3843-3852.
［11］WANG Q,CAO B,PENG L,et al.Development and validation of a practical prognostic coagulation index for patients with esophageal squamous cell cancer［J］.Ann Surg Oncol,2021,28(13):8450-8461.
［12］SILVA JP,BERGER NG,TSAI S,et al.Transarterial chemoembolization in hepatocellular carcinoma with portal vein tumor thrombosis:a systematic review and meta-analysis［J］.HPB(Oxford),2017,19(8):659-666.
［13］PYO JS,SOHN JH,KANG G.Diagnostic and prognostic roles of the mean platelet volume in malignant tumors:a systematic review and meta-analysis［J］.Platelets,2016,27(8):722-728.
［14］KORNILUK A,KOPER-LENKIEWICZ OM,KAMINSKA J,et al.Mean platelet volume (MPV):New perspectives for an old marker in the course and prognosis of inflammatory conditions［J］.Mediators Inflamm,2019,36(12):9213074.
［15］CHEN H,YANG R,YU X,et al.Establishment of a preoperative laboratory panel to identify lymph node metastasis in superficial esophageal cancer［J］.J Cancer,2022,13(7):2238-2245.

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河北省2020年度医学科学研究课题计划（编号：20200334）；河北省邯郸市科学技术研究与发展计划项目（编号： 22422083024ZC）
Last Update: 1900-01-01