|Table of Contents|

Analysis of clinicopathological features of primary sinonasal adenocarcinoma（3 cases）

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 14
Page:
2647-2650
Research Field:
Publishing date:

Info

Title:
Analysis of clinicopathological features of primary sinonasal adenocarcinoma（3 cases）
Author(s):
YANG Wei; ZHANG Yuhang; TANG Hong; LIU Yong
Department of Pathology，the Affiliated Hospital of Southwest Medical University，Sichuan Luzhou 646000,China.
Keywords:
sinonasal; ITAC; non-ITAC; prognosis
PACS:
R739.62
DOI:
10.3969/j.issn.1672-4992.2023.14.013
Abstract:
Objective:To investigate the clinicopathological features,diagnosis and differential diagnosis,treatment and prognosis of primary sinonasal adenocarcinoma.Methods:The clinical data,imaging findings,pathological characteristics of three cases of primary sinonasal adenocarcinoma which were diagnosed in our hospital from 2015 to 2022 were collected and analyzed,and relevant domestic and foreign literatures were reviewed.Results:There were 3 males with an average age of 68 years.And none had a long-term exposure to wood dust or leather dust.The histological types were respectively intestinal-type adenocarcinoma(ITAC),high-grade non-intestinal-type adenocarcinoma(non-ITAC),and low-grade non-intestinal-type adenocarcinoma.They had similar clinical symptoms of the nasal obstruction and epistaxis.There was no specific evidence for cancer in their CT and MR imaging findings.Microscopically,the ITAC showed prominent papillary fronds with tubular-glandular pattern.And necrosis was visible.The high-grade non-ITAC showed a distinctly invasive growth pattern with solid hyperplasia and obvious nuclear pleomorphism.Necrosis was visible,too.While the low-grade non-ITAC showed a characteristic complex glandular growth pattern with back-to-back glands.The tumour cells are uniform with regular rounded nuclei.Molecular pathology:The BRAF mutation was not detected in the three cases.All the three patients accepted complete surgical resection or surgical resection with postoperative radiotherapy/chemotherapy management.The patient with ITAC and the another patient with high-grade non-ITAC both died several months later,while the patient with low-grade non-ITAC had no recurrence or metastasis.Conclusion:Primary sinonasal adenocarcinoma is rare.It has no specific clinical or imaging manifestations.And the diagnosis relies mainly on histology.Immunohistochemistry and molecular pathology can assist in the diagnosis and provide guidance for treatment and prognostic monitoring.

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