|Table of Contents|

Analysis of the influencing factors of surgical site infection and the changes of serum MCP1，CA72-4 and sCD14 levels after radical resection of gastric cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 12
Page:
2264-2270
Research Field:
Publishing date:

Info

Title:
Analysis of the influencing factors of surgical site infection and the changes of serum MCP1，CA72-4 and sCD14 levels after radical resection of gastric cancer
Author(s):
ZHANG Chengrong; WANG Feng; PANG Sisi; LI Peng; Airexiati·Tuhongjiang; QU Yujiang
Day Ward of Xinjiang Uygur Autonomous Region People's Hospital,Xijiang Urumqi 830000,China.
Keywords:
primary gastric cancer; radical gastric cancer; surgical site infection; influencing factors; MCP1; CA72-4; sCD14
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2023.12.016
Abstract:
Objective:To explore the influencing factors of surgical site infection（SSI) after radical gastric cancer surgery and serum monocyte chemoattractant protein-1（MCP1)，carbohydrate antigen 72-4（CA72-4)，soluble cluster of differentiation antigen-14（sCD14) significance of level changes.Methods:A total of 150 patients undergoing radical gastric cancer surgery in our hospital from February 2017 to January 2021 were selected as the research objects.The patients were divided into two groups according to whether the patients had SSI after surgery，the infection group（n=35) and the non-infection group（n=115).Compare the clinical data of the two groups，serum MCP1，CA72-4，and sCD14 levels before and after surgery，analyze the influencing factors of SSI after radical gastric cancer and draw receiver operating characteristic curve（ROC)，and evaluate the effects of serum MCP1，CA72-4 and sCD14 levels on gastric cancer.The diagnostic value of SSI after radical surgery and analyze the correlation between postoperative serum MCP1，CA72-4，sCD14 levels and the degree of infection（IPS score)，and compare the mortality of patients with high and low levels of serum MCP1，CA72-4，sCD14 after surgery.Results:There were significant differences between the two groups in age，operation method，clinical stage，operation time，and diabetes（P＜0.05).The postoperative serum MCP1，CA72-4，and sCD14 levels in the infected group were higher than those in the non-infected group（P＜0.05).Logistic regression equation showed that age,clinical stage,diabetes,operation mode,operation time and postoperative serum levels of MCP1,CA72-4 and sCD14 were all independent risk factors for SSI after radical gastrectomy（P＜0.05).The ROC curve of the diagnostic value of serum MCP1, CA72-4 and sCD14 after radical gastrectomy was drawn.The results showed that the area under curve(AUC) of serum MCP1, CA72-4 and sCD14 after radical gastrectomy was 0.804, 0.768 and 0.777, respectively.Logistic binary regression fitting was used to construct the AUC of joint diagnosis of each index.The results showed that the AUC of joint detection was 0.912.The IPS score of SSI patients after radical gastrectomy was (13.89±6.52).Pearson correlation analysis showed that postoperative serum MCP1，CA72-4，sCD14 levels of SSI patients after radical gastric cancer surgery were positively correlated with the degree of infection（P＜0.05).According to the postoperative serum MCP1，CA72-4，sCD14 levels for the high-level group and the low-level group，the postoperative serum MCP1，CA72-4，sCD14 high-level mortality rate was significantly higher than that of the low-level group，and the difference was statistically significant（P＜0.05).Conclusion:Factors influencing the development of SSI after radical gastric cancer surgery include age，clinical stage，diabetes mellitus，surgical method，time of surgery and postoperative serum MCP1，CA72-4 and sCD14 levels，and clinical detection of postoperative serum MCP1，CA72-4 and sCD14 levels is of great value in the diagnosis，disease assessment and prognosis prediction of SSI.

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新疆维吾尔自治区自然科学基金资助项目(编号：2022D01C141)
Last Update: 1900-01-01