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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2023 11

Page:

2086-2094

Research Field:

Publishing date:

Info

Title:

Clinicopathological characteristics and proteomic study of 18 cases of solitary fibrous tumors

Author(s):

ZHANG Zhanzhi¹; 2; LIU Xingkai³; YAN Fengcai⁴; RAO Benqiang¹; 2; WANG Fuyi³; SHI Hanping¹; 2

1.Department of General Surgery，Beijing Shijitan Hospital，Capital Medical University，Beijing 100038，China;2.Key Laboratory of Cancer FSMP for State Market Regulation，Beijing 100038，China;3.Institute of Chemistry，Chinese Academy of Sciences，Beijing 100190，China;4.Department of Pathology，Beijing Shijitan Hospital，Capital Medical University，Beijing 100038，China.

Keywords:

solitary fibrous tumors; clinical; pathology; proteomic

PACS:

R738.6

DOI:

10.3969/j.issn.1672-4992.2023.11.021

Abstract:

Objective:To study the recurrence characteristics of patients with solitary fibrous tumors and the pathological characteristics of each surgical specimen，and to analyze the biological behavior characteristics of solitary fibrous tumors，so as to select the best treatment for patients，so as to obtain greater clinical benefits and longer survival time.Methods:The clinical and pathological data of 18 patients who underwent resection of solitary fibrous tumors in our hospital from November 1，2011 to May 31，2019 were retrospectively studied（3 patients who had been operated in other hospital borrowed medical records and pathological specimens).The clinical data and pathological features were analyzed comprehensively.The proteomic changes of tumor microenvironment in 16 solitary fibrous tumors were compared.Results:During the follow-up period，the survival time of 18 patients after operation ranged from 1 month to 213 months，with an average survival time of 57.9 months.Among the 6 patients who underwent reoperation after recurrence，3 died of disease progression，2 patients survived with tumors，and 1 patient was cured.The times of operations ranged from 2 to 5.Among the 6 patients who underwent reoperation after recurrence，5 patients had 2 or more recurrences，of which 4 patients had a decreasing interval of recurrence.Among the 6 patients who underwent reoperation after recurrence，with the increase of recurrence times，the mitotic image and the positive rate of Ki-67 increased significantly.The pathological results gradually changed from benign to borderline or even malignant.It was suggested that the malignant degree of the tumor specimens in patients with recurrent solitary fibrous tumors increases with the times of operations.The tumors of 4 patients who died as a result of the progression of the tumors all originated from the abdominal cavity and pelvic cavity.Proteomic studies found that the expression of processing of RNA and splicing of RNA-related proteins in tumors was up-regulated，and the expression level of neutrophil-related proteins in tumor microenvironment was increased.Conclusion:Solitary fibrous tumors is prone to recurrence after surgery.The more reoperations，the shorter the recurrence interval，and the degree of malignancy increases with the times of operations.Extending the observation time after recurrence and minimizing the times of operations may achieve better survival benefits for patients.Solitary fibrous tumors from abdominal and pelvic sources is more invasive and prone to death.Solitary fibrous tumors may secrete growth-promoting factors，or the hormones synthesized by the human body to promote cell tissue and biogenesis significantly decrease after tumor resection.The analysis of proteomic research results found that the inflammatory reaction caused by surgical trauma led to the enrichment of immune-related proteins in the focus and the formation of a large number of capillaries in the tumor，leading to the proliferation and metastasis of tumor cells.

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Memo

Memo:

国家重点研发计划项目(编号：2022YFC2009600)

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Last Update: 2023-04-28