|Table of Contents|

Predictive value of nutritional risk index in elderly patients undergoing radical resection of rectal cancer after neoadjuvant therapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 11
Page:
2063-2068
Research Field:
Publishing date:

Info

Title:
Predictive value of nutritional risk index in elderly patients undergoing radical resection of rectal cancer after neoadjuvant therapy
Author(s):
FU Weibo; ZHANG Lei; WU Chenxi; SHE Junjun
Department of General Surgery,the First Affiliated Hospital of Xi'an Jiaotong University，Shaanxi Xi'an 710061，China.
Keywords:
geriatric nutritional risk index; neoadjuvant therapy; rectal neoplasm; postoperative complications; short-term outcomes
PACS:
R735.3
DOI:
10.3969/j.issn.1672-4992.2023.11.017
Abstract:
Objective:To evaluate the predictive value of geriatric nutritional risk index（GNRI) in postoperative short-term outcomes of patients undergoing radical resection of rectal cancer after neoadjuvant therapy.Methods:The clinicopathologic data of 393 patients with rectal cancer underwent radical resection after neoadjuvant therapy admitted in our hospital from January 2018 to December 2021 who met the inclusion and exclusion criteria were retrospectively collected.393 patients were divided into normal GNRI group and low GNRI group according to preoperative GNRI level.Baseline data of the two groups were matched 1∶1 by propensity scores match（PSM).The short-term outcomes of the two matched groups was compared.Univariate and multivariate logistic regression were used to analyze the independent risk factors for postoperative complications（Clavien-Dindo grade≥Ⅱ) in patients undergoing radical resection of rectal cancer after neoadjuvant therapy.Results:After PSM，114 cases in each of the two groups were included in the matching study.The incidence of postoperative complications was significantly higher in the low preoperative GNRI group than in the normal preoperative GNRI group（31.6% vs 17.5%，P=0.014).The total cost of postoperative hospitalization in the low preoperative GNRI group was significantly higher than that in the normal preoperative GNRI group（84 000 yuan vs 74 000 yuan，P=0.031).In multivariate logistic regression analysis，preoperative GNRI level（<93.7，OR=3.580，95%CI:1.546~8.293，P=0.003)，cT stage（T3-4，OR=2.615，95%CI：1.264~5.409，P=0.010)，ASA grading（level Ⅲ or Ⅳ，OR=1.533，95%CI：1.068~2.201，P=0.021)，and open surgery（OR=6.589，95%CI：2.466~17.602，P＜0.001) were the independent risk factors for postoperative complications in patients undergoing radical resection of rectal cancer after neoadjuvant therapy. Conclusion:Preoperative GNRI level can be used to evaluate the short-term prognosis of patients undergoing radical resection of rectal cancer after neoadjuvant therapy，which is helpful to provide reference for clinical diagnosis and treatment，and timely intervention to improve the short-term prognosis of patients.

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Memo

Memo:
西安交通大学第一附属医院临床研究课题（编号：XJTU1AF2020LSL-004）
Last Update: 2023-04-28