|Table of Contents|

Expression of centrosome associated protein 55 in tissues and cells of cholangiocarcinoma and its clinical significance

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 11
Page:
2057-2062
Research Field:
Publishing date:

Info

Title:
Expression of centrosome associated protein 55 in tissues and cells of cholangiocarcinoma and its clinical significance
Author(s):
LU Zefa1; SHAO Zicheng1; ZHANG Yaodong2; LI Xiangcheng2
1.Department of Hepatobiliary Surgery，the First People＇s Hospital of Nantong，the Second Affiliated Hospital of Nantong University，Jiangsu Nantong 226000,China;2.Liver Transplant Center，the First Affiliated Hospital of Nanjing Medical University，Jiangsu Nanjing 210029,China.
Keywords:
cholangiocarcinoma; CEP55; proliferation
PACS:
R735.8
DOI:
10.3969/j.issn.1672-4992.2023.11.016
Abstract:
Objective:To investigate the expression of CEP55 in cholangiocarcinoma tissues and cells and its effect on the proliferation of cholangiocarcinoma cells by knockdown of CEP55.Methods：The expression of CEP55 in cholangiocarcinoma tissues and cell lines was studied by RT-PCR,Western blot and immunohistochemistry.The functional effects of CEP55 knockdown on cholangiocarcinoma cell lines were studied by CCK8,plate cloning and EDU tests in vitro.Results：CEP55 was overexpressed in cholangiocarcinoma tissues and cell lines.Cell function tests showed that knockdown of CEP55 could reduce the proliferation ability of cholangiocarcinoma cells.Clinical prognostic analysis showed that patients with high CEP55 expression had poor prognosis.Conclusion：CEP55 is overexpressed in cholangiocarcinoma,which can promote the proliferation of cholangiocarcinoma cells.Patients with high CEP55 expression level have a poor prognosis.

References:

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江苏省南通市科学技术局基础科学课题（编号：JCZ21092）
Last Update: 2023-04-28