|Table of Contents|

Expression of CCR8 and Tregs in triple-negative breast cancer tissues and their clinical significance

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 10
Page:
1848-1853
Research Field:
Publishing date:

Info

Title:
Expression of CCR8 and Tregs in triple-negative breast cancer tissues and their clinical significance
Author(s):
ZHAO Yuzhe1; WANG Tingting2; ZHAO Yihan2; ZHANG Hongzhen3
1.Department of Glandular Surgery;3.No.5 Department of Oncology,Hebei General Hospital，Hebei Shijiazhuang 050051，China;2.Graduate School,Hebei Medical University,Hebei Shijiazhuang 050017,China.
Keywords:
triple-negative breast cancer; chemokine receptor 8; regulatory T cells; prognosis
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2023.10.014
Abstract:
Objective:To study the expression and clinical significance of chemokine receptor 8 (CCR8) and regulatory T cells (Tregs) in triple-negative breast cancer (TNBC) tissues.Methods:The transcription factor forkhead box P3 protein (Foxp3) was regarded as a molecular marker of Tregs,and we analyzed the expression of CCR8 and Foxp3 in 90 cases of TNBC and 30 cases of adjacent tissue samples,analyzed the relationship between their expressions and the clinico-pathological features and prognosis of TNBC patients,and explored whether their expressions were related.Multivariate Cox regression analysis model was used to explore the prognostic factors of patients with TNBC.Results:The expression of both CCR8 and Foxp3+Tregs was significantly higher in TNBC tissues than in adjacent tissues (both P＜0.001).The expression of CCR8 and Foxp3+Tregs in TNBC tissues with late TNM stage and lymph node metastasis increased significantly (both P＜0.05),but their expressions were irrelevant to age,tumor size and histological grades (all P>0.05).The expression of CCR8 and Foxp3+Tregs in TNBC tissues was positively correlated (r=0.278,P＜0.05).Up to the last follow-up time,the 5-year disease-free survival (DFS) rate and overall survival (OS) rate of CCR8 negative patients were significantly higher than those of CCR8 positive patients (P＜0.05).The 5-year DFS rate and OS rate of Foxp3+Tregs negative patients were higher than those of Foxp3+Tregs positive patients,but the difference was not statistically significant (P>0.05).Kaplan-Meier survival curve showed that the survival of patients with co-negative expression of CCR8 and Foxp3+Tregs was significantly better than that of patients with co-positive expression,but but the difference was not statistically significant (P>0.05).Multivariate Cox regression model showed that TNM stage and expression of CCR8 were independent factors influencing the prognosis of TNBC patients.Conclusion:Both CCR8 and Foxp3+Tregs are highly expressed in TNBC,and there is a positive correlation between them,and both of them are correlated with poor prognosis.The expression of CCR8 is an independent factor affecting the poor prognosis of patients,and may become a new prognostic marker of TNBC,which provides new thinking for the immunotherapy strategy of TNBC.

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河北省医学科学研究重点课题计划（编号:20180164）
Last Update: 1900-01-01