|Table of Contents|

Application of neuronavigation combined with fluorescein sodium in low-grade glioma surgery

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 10
Page:
1833-1838
Research Field:
Publishing date:

Info

Title:
Application of neuronavigation combined with fluorescein sodium in low-grade glioma surgery
Author(s):
LING Guoyuan; MO Ligen; GUO Fangzhou; DENG Teng; HUANG Qianrong; JIANG Qian; WEN Liangbao; SHI Liu
Department of Neurosurgery,Affiliated Tumor Hospital of Guangxi Medical University,Guangxi Nanning 530021,China.
Keywords:
glioma; neuronavigation; fluorescein sodium; neurosurgery
PACS:
R730.264
DOI:
10.3969/j.issn.1672-4992.2023.10.011
Abstract:
Objective:To evaluate the safety and efficacy of intraoperative neuronavigation combined with sodium fluorescein in low-grade glioma surgery.Methods:The clinical data of 21 patients with low-grade glioma (LGG) were classified into routine operation group,forty-six patients with LGG were enrolled in the study using fluorescein sodium (FLS) at a dose of 5 mg/kg (21 patients in the conventional dose group) and 1 mg/kg (25 patients in the low dose group) in combination with neuronavigation surgery,respectively,the operative effect and KPS score at 6 months after operation were compared among the 3 groups.Results:The total tumor resection rates of the conventional dose group,the low dose group and the conventional surgery group were 81.0%(17/21),76.0%(19/25) and 42.9%(9/21),respectively,the extent of tumor resection,operative time,blood loss and KPS score at 6 months after operation were compared among the 3 groups,there was significant difference between the routine dose group and the low dose group (P＜0.05),but there was no significant difference between the routine dose group and the low dose group (P>0.05).There was no significant difference in the complications among the three groups (P>0.05).The developing rate of conventional dose group and low dose group was 76.2%(16.21) and 68.0%(17/25) respectively,there was no significant difference between the two groups ［(χ2=1.665,P=0.645),(χ2=0.378,P=0.539)］,there was no significant difference between the two groups in developing and neuronavigation concordance (χ2=0.874,P=0.350).Conclusion:FLS of two doses (5 mg/kg,1 mg/kg) can achieve good fluorescence imaging effect in the operation of LGG.The application of FLS combined with neuronavigation can increase the total resection rate of tumor and improve the prognosis of patients.

References:

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