|Table of Contents|

Clinical characteristics,gene mutation and treatment of core binding factor-acute myeloid leukemia

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 09
Page:
1769-1774
Research Field:
Publishing date:

Info

Title:
Clinical characteristics,gene mutation and treatment of core binding factor-acute myeloid leukemia
Author(s):
SHI ChaojunSU YanhuaGAO YujuanSUN Jiayue
Department of Hematology,the First Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150000,China.
Keywords:
CBF-AMLgene-mutationclinical-featuresprognosistreatment
PACS:
R733
DOI:
10.3969/j.issn.1672-4992.2023.09.036
Abstract:
Core binding factor-acute myeloid leukemia(CBF-AML) is a group of heterogeneous diseases.The prognosis of CBF-AML is better than that of normal and other abnormal karyotype leukemia,but some patients are prone to relapse.Studies have found that the presence of additional cytogenetic abnormalities in this type of leukemia is suggestive of prognosis,and patients with CBF-AML are often accompanied by simultaneous mutations in one or more genes,among which the incidence of mutations in tyrosine kinase pathway,epigenetic modification genes and tumor suppression related genes is higher.These gene mutations will affect the prognosis of patients.Early detection,corresponding diagnosis and stratification have guiding significance for the treatment of patients with CBF-AML.Targeted therapy for these genes or combined therapy with chemotherapy can improve the prognosis of patients with CBF-AML.

References:

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Last Update: 2023-03-30