|Table of Contents|

Expression of PTEN and Beclin-1 in children with non-Hodgkin' s lymphoma tissues and its clinical significance

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 09
Page:
1715-1720
Research Field:
Publishing date:

Info

Title:
Expression of PTEN and Beclin-1 in children with non-Hodgkin' s lymphoma tissues and its clinical significance
Author(s):
CHEN Kaiwen; JIANG Lian; ZHU Xiuli; CHEN Jian; LIU Sufen; JI Huijuan
Department of Pediatrics,the Fourth Hospital of Hebei Medical University，Hebei Shijiazhuang 050011，China.
Keywords:
PTEN; Beclin-1; children's NHL; immunohistochemistry; diagnosis; prognostic
PACS:
R733
DOI:
10.3969/j.issn.1672-4992.2023.09.025
Abstract:
Objective：To investigate the expression characteristics and clinical significance of PTEN and Beclin-1 in children's non-Hodgkin's lymphoma.Methods：The expression of PTEN and Beclin-1 was detected by immunohistochemistry.The positive expression rates of these two proteins in NHL（non-Hodgkin lymphoma）and RH（reactive hyperplasia） tissues were compared by chi-square test.Theirs correlation with clinicopathologic features(gender，age，T/B classification，St.Jude stage，LDH level，clinical symptoms of group B or not，Ki-67 and IPI risk) and the relation between themselves were further researched.This study complied with the ethical standards set by the ethics committee.Results：The positive expression rate of PTEN in children with NHL was 47.2%，lower than RH tissue(80.8%)（χ2=7.161，P＜0.05）.PTEN protein expression was correlated with IPI risk stratification and LDH level in NHL children(P＜0.05).The positive expression rate of Beclin-1 in children with NHL was 50.0%，lower than RH tissue(84.6%)（χ2=7.902，P＜0.05）.The expression of Beclin-1 was not related to clinicopathologic factors.A positive correlation was discovered between the expression of PTEN and Beclin-1 in children with NHL(r=0.501，P<0.05).Conclusion：PTEN and Beclin-1 are deleted or lost expressed in children with NHL，this maybe a factor contributing to occurrrence or development of disease.The two kinds of tumor suppressor gene maybe cooperate in children NHL，joint detection probably contributes to the diagnosis and prognostic judgement.

References:

［1］LEE YR，CHEN M，PANDOLFI PP.The functions and regulation of the PTEN tumour suppressor：new modes and prospects［J］.Nature Reviews Molecular Cell Biology，2018，19(9):547-562.
［2］孙建伟，郑立民.抑癌基因PTEN的研究进展［J］.中国当代医药，2019，26（13）:19-22. SUN JW，ZHENG LM.Research progress of tumor suppressor gene PTEN［J］.Chinese Contemporary Medicine，2019，26（13）:19-22.
［3］李季林，肖建，于如同.肿瘤抑制基因PTEN研究新进展［J］.现代肿瘤医学，2010，18(5):1034-1037. LI JL，XIAO J，YU RT.Recent advances in the study of tumor suppressor gene PTEN［J］.Modern Oncology，2010，18(5):1034-1037.
［4］姜蓬垒，常冰梅.PI3K-Akt信号通路与肿瘤化疗耐药性［J］.国际肿瘤学杂志，2014，41(5):324-327. JIANG PL，CHANG BM.PI3K-Akt signaling pathway and chemotherapy drug resistance in cancer［J］.Journal of International Oncology，2014，41(5):324-327.
［5］ZHENG Z，WANG L，CHENG S，et al.Autophagy and myeloma［J］.Adv Exp Med Biol，2020，12(7)：625-631.
［6］XU HD，QIN ZH.Beclin 1，Bcl-2 and autophagy［J］.Adv Exp Med Biol，2019，12(6)：109-126.
［7］TERAMAE S，MUGURUMA N，OKAMOTO K，et al.Cancer risk and genotype-phenotype correlation in Japanese patients with Cowden syndrome［J］.Int J Clin Oncol，2022，27(4):639-647.
［8］DAI YX，WAN YK，QIU MK，et al.lncRNA MEG3 suppresses the tumorigenesis of hemangioma by sponging miR-494 and regulating PTEN/PI3K/AKT pathway［J］.Cell Physiol Biochem，2018，51（6）：2872-2886.
［9］杨槟伊，陈伟明，尉嘉斌，等.miR-92a-3p靶向调控PTEN对神经母细胞瘤细胞增殖、侵袭和迁移的影响［J］.中华小儿外科杂志，2022，43(3):257-264. YANG BY，CHEN WM，WEI JB，et al.miR-92a-3p targets the effects of PTEN on the proliferation，invasion and migration of neuroblastoma cells［J］.Chinese Journal of Pediatric Surgery，2022，43(3):257-264.
［10］HE YY，ZHAO XD，SUBAHAN NR，et al.The prognostic value of autophagy-related markers Beclin-1 and microtubule-associated protein light chain 3B in cancers：a systematic review and meta-analysis［J］.Tumour Biol，2014，35(8)：7317-7326.
［11］ALABIAD M，HARB O，MANDOUR D，et al.Prognostic and clinicopathological implications of expression of Beclin-1 and hypoxia-inducible factor 1α in serous ovarian carcinoma：an immunohistochemical study［J］.Pol J Pathol，2021，72(1)：23-38.
［12］MAIURI MC，TASDEMIR E，CRIOLLO A，et al.Control of autophagy by oncogenes and tumor suppressor genes［J］.Cell Death Differ，2009，16(1)：87-93.
［13］HOPKINS BD，FINE B，STEINBACH N，et al.A secreted PTEN phosphatase that enters cells to alter signaling and survival［J］.Science，2013，341(6144):399-402.
［14］NAZIRI H，TAHAMTAN A，DADMANESH M，et al.Antitumor effects of HPV DNA vaccine adjuvanted with Beclin-1 as an autophagy inducer in a mice model［J］.Iran Biomed J，2019，23(6):388-394.
［15］RAHMATI M，EBRAHIM S，HASHEMI S，et al.New insigｈts on tｈe roｌe of ａutopｈａgy in tｈe pａtｈogenesis ａnd treａtment of melanoma［J］.Mol Biol Rep，2020，47（11）：9021-9032.

Memo

Memo:
-
Last Update: 2023-03-30