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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2023 08

Page:

1554-1558

Research Field:

Publishing date:

Info

Title:

Research progress on the relationship between KPNA2 and bladder cancer

Author(s):

YAN Zhangzhe¹; 2; LI Zengjun¹

1.Endoscopy Department,Shandong Cancer Prevention Institute (Shandong Cancer Hospital),Shandong Jinan 250000,China;2.Endoscopy Department,Shandong First Medical University (Shandong Academy of Medical Sciences),Shandong Jinan 250000,China.

Keywords:

bladder cancer; nuclear transport protein ¦Á2; diagnosis; treatment; prognosis

PACS:

R737.14

DOI:

10.3969/j.issn.1672-4992.2023.08.031

Abstract:

Nuclear transport protein ¦Á2 (KPNA2) is one of the important members of the nuclear transport protein family,which is involved in a variety of life activities and interacts with a variety of tumor-related proteins.KPNA2 plays an important role in cellular activities such as cell cycle regulation,transcriptional regulation,apoptosis and DNA repair.Bladder cancer is a common malignant tumor.Exploring the relationship between KPNA2 and bladder cancer can help early diagnosis of bladder cancer,study the mechanism of KPNA2 proliferation and migration in bladder cancer cells,and predict the prognosis of bladder cancer patients.KPNA2 knockdown may increase the sensitivity of bladder cancer cells to cisplatin chemotherapy,thereby effectively inhibiting tumor cell proliferation,promoting their apoptosis,improving patient prognosis and prolonging survival.

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Memo

Memo:

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