|Table of Contents|

Expression of LncRNA ANRIL and LncRNA MALAT1 in peripheral blood of children with limb osteosarcoma and their relationship with prognosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 08
Page:
1507-1511
Research Field:
Publishing date:

Info

Title:
Expression of LncRNA ANRIL and LncRNA MALAT1 in peripheral blood of children with limb osteosarcoma and their relationship with prognosis
Author(s):
WU Hao1; 2; LI Qing3
1.The School of Clinical Medicine,Guizhou Medical University,Guizhou Guiyang 550004,China;2.Department of Pediatric Surgery,Guizhou Cancer Hospital,Guizhou Guiyang 550001,China;3.Department of Trauma and Orthopedics,Affiliated Hospital of Guizhou Medical University,Guizhou Guiyang 550004,China.
Keywords:
pediatric limb osteosarcoma; LncRNA ANRIL; LncRNA MALAT1; prognosis
PACS:
R738
DOI:
10.3969/j.issn.1672-4992.2023.08.022
Abstract:
Objective:To investigate the expression of LncRNA ANRIL and LncRNA MALAT1 in peripheral blood of children with limb osteosarcoma and their relationship with prognosis.Methods:The 93 children with osteosarcoma of extremities in our hospital from September 2016 to September 2021 were selected as the study subjects.In addition,50 children with physical examination in our hospital from September 2016 to September 2021 were selected as the control group.The relative expression of LncRNA ANRIL and LncRNA MALAT1 in peripheral blood was measured by real-time quantitative PCR (qRT-PCR).The patients were followed up to August 31,2022,and the total survival period (OS) was recorded.The relative expression levels of LncRNA ANRIL and LncRNA MALAT1 in peripheral blood of the two groups were compared.The relative expression of LncRNA ANRIL and LncRNA MALAT1 in osteosarcoma with different pathological characteristics were compared.The prognosis was correlated with the relative expression of LncRNA ANRIL and LncRNA MALAT1 were compared.Multivariate Logistic regression analysis was used to analyze the independent risk factors affecting the prognosis of children with osteosarcoma.Results:The relative expression of LncRNA ANRIL and LncRNA MALAT1 in peripheral blood of osteosarcoma group was higher than control group (P＜0.05).There was no significant difference in the relative expression of LncRNA ANRIL and LncRNA MALAT1 in peripheral blood between different genders,ages,histological types and disease sites (P＞0.05).The relative expression of LncRNA ANRIL and LncRNA MALAT1 in phase III peripheral blood was higher than phase I and II (P＜0.05).Children with limb osteosarcoma were followed up for 12 to 72 months,with a median follow-up of 43 months.The OS time of high expression of LncRNA ANRIL was shorter than that of low expression of LncRNA ANRIL (P＜0.05).The OS time of high expression of LncRNA MALAT1 was shorter than that of low expression of LncRNA MALAT1 (P＜0.05).Multivariate Logistic regression analysis showed that Enneking stage Ⅲ,high expression of LncRNA ANRIL and high expression of LncRNA MALAT1 were independent risk factors affecting the prognosis of children with osteosarcoma.Conclusion:The overexpression of LncRNA ANRIL and LncRNA MALAT1 in peripheral blood of children with limb osteosarcoma is closely related to Enneking stage and prognosis,and the overexpression of LncRNA ANRIL and LncRNA MALAT1 is an independent risk factor affecting the prognosis of osteosarcoma.

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Memo

Memo:
National Natural Science Foundation of China（No.81960234）;国家自然科学基金（编号：81960234）
Last Update: 1900-01-01