|Table of Contents|

Correlation analysis of ATM gene polymorphisms with breast cancer risk and clinicopathological features

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 08
Page:
1456-1461
Research Field:
Publishing date:

Info

Title:
Correlation analysis of ATM gene polymorphisms with breast cancer risk and clinicopathological features
Author(s):
PAN Siqiong1; QIAO Shuye1; LU Fengke2; YI Min1
1.The Fourth Affiliated Hospital of Guangxi Medical University,Guangxi Liuzhou 545000,China;2.Liuzhou Maternal and Child Health Hospital,Guangxi Liuzhou 545001,China.
Keywords:
breast cancer; ATM; gene polymorphism; clinicopathological features
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2023.08.012
Abstract:
Objective:To investigate the relationship between two loci polymorphisms,rs189037 and rs609261,of ataxia-telangiectasia mutated gene (ATM) single nucleotide polymorphisms and breast cancer and clinicopathological features.Methods:Radical breast cancer specimens and benign breast tumor specimens from our hospital who did not receive radiotherapy and chemotherapy were collected.Multiplex SNaPshot method was used to detect the polymorphisms of two loci of ATM gene rs189037 and rs609261,and their relationship with breast cancer risk and clinicopathological characteristics was analyzed.Results:The rs189037 polymorphism of ATM gene was not associated with breast cancer risk and clinicopathological characteristics (GA genotype,P=0.667).The cancer risk of lymph node metastasis patients with TC and CC genotypes at rs609261 was higher than that of TT gene Type carriers (TC+CC dominant model,P=0.015).The allele frequency and genotype distribution of the ATM gene rs189037 and rs609261 have no correlation with the immunohistochemical indicators (ER,PR,HER2,Ki-67) (the rs189037 locus GA+AA dominant model and the rs609261 locus) TC+CC dominant model,ER:P=0.676,0.675;PR:P=0.758,0.573;HER2:P=0.203,0.327;Ki-67:P=0.189,0.405).Conclusion:There is no significant correlation between the rs189037 locus of ATM gene and breast cancer risk,clinicopathological features and immunohistochemical indexes.Lymph node metastasis patients with TC and CC genotypes at the rs609261 locus may increase the risk of disease.

References:

［1］ 王维娜,陈海霞,张银华,等.双侧原发性乳腺癌90例临床病理及预后分析［J］.临床与实验病理学杂志,2022,38(01):9-15. WANG WN,CHEN HX,ZHANG YH,et al.Clinicopathological and prognostic analysis of 90 cases of bilateral primary breast cancer ［J］.Journal of Clinical and Experimental Pathology,2022,38(01):9-15.
［2］ ZHAO T,MENG W,CHIN Y,et al.Identification of miR-25-3p as a tumor biomarker:regulation of cellular functions via TOB1 in breast cancer ［J］.Mol Med Rep,2021,23(6):406.
［3］ LUKASIEWICZ S,CZECZELEWSKI M,FORMA A,et al.Breast cancer-epidemiology,risk factors,classification,prognostic markers,and current treatment strategies-an updated review［J］.Cancers (Basel),2021,13(17):4287.
［4］ ZHOU H,HEN H,HENG C,et al.A quality evaluation of the clinical practice guidelines on breast cancer using the right checklist ［J］.Ann Transl Med,2021,9(14):1174.
［5］ SMITH SG,SESTAK I,MORRIS MA,et al.The impact of body mass index on breast cancer incidence among women at increased risk:an observational study from the international breast intervention studies ［J］.Breast Cancer Res Treat,2021,188(1):215-223.
［6］ DALY AA,ROLPH R,CUTRESS RI,et al.A review of modifiable risk factors in young women for the prevention of breast cancer ［J］.Breast Cancer (Dove Med Press),2021,13:241-257.
［7］ HU C,HART SN,GNANAOLIVU R,et al.A population-based study of genes previously implicated in breast cancer ［J］.N Engl J Med,2021,384(5):440-451.
［8］ XIE X,ZHANG Y,WANG Z,et al.ATM at the crossroads of reactive oxygen species and autophagy ［J］.Int J Biol Sci,2021,17(12):3080-3090.
［9］ UENO S,SUDO T,HIRASAWA A.ATM:functions of ATM kinase and its relevance to hereditary tumors［J］.Int J Mol Sci,2022,23(1):523.
［10］ EVANS DG,HOWELL SJ,GANDHI A,et al.Breast cancer incidence and early diagnosis in a family history risk and prevention clinic:33-year experience in 14,311 women［J］.Breast Cancer Res Treat,2021,189(3):677-687.
［11］ PHAN LM,REZAEIAN AH.ATM:main features,signaling pathways,andits diverse roles in DNA damage response,tumor suppression,and cancer development ［J］.Genes (Basel),2021,12(6):845.
［12］ MOSLE M,MORADI Y,DEHGHANBANADA H,et al.The association between ATM variants and risk of breast cancer:a systematic review and meta-analysis［J］.BMC Cancer,2021,21(1):27.
［13］ PUTTI S,GIOVINAZZO A,MEROLLE M,et al.ATM kinase dead:from ataxia telangiectasia syndrome to cancer ［J］.Cancers (Basel),2021,13(21):5498.
［14］ ZHANG JQJ,SARAVANABAVAN S,RANGAN GK.Effect of reducing ataxia-telangiectasia mutated (ATM) in experimental autosomal dominant polycystic kidney disease ［J］.Cells,2021,10(3):532.
［15］ MOSLEMI M,VAFAEI M,KHANI P,et al.The prevalence of ataxia telangiectasia mutated (ATM) variants in patients with breast cancer patients:a systematic review and meta-analysis［J］.Cancer Cell Int,2021,21(1):474.
［16］ STUCCI LS,INTERN V,TUCCI M,et al.The ATM gene in breast cancer:its relevance in clinical practice ［J］.Genes (Basel),2021,12(5):727.
［17］ DUECKER RP,GTONAU L,BAER PC,et al.Survival and functional immune reconstitution after haploidentical stem cell transplantation in ATM-deficient mice［J］.Front Immunol,2021,12:693897.
［18］ CHEN H,YE Z,XU X,et al.ALDOA inhibits cell cycle arrest induced by DNA damage via the ATM-plk1 pathway in pancreatic cancer cells［J］.Cancer Cell Int,2021,21(1):514.
［19］ SAUNDERS RA,MICHNIACK TF,HAMES C,et al.Elevated inflammatory responses and targeted therapeutic intervention in a preclinical mouse model of ataxia-telangiectasia lung disease ［J］.Sci Rep,2021,11(1):4268.
［20］ DALMASSO B,PASTORINO L,NATHAN V,et al.Germline ATM variants predispose to melanoma:a joint analysis across the genomel and melanostrum consortia ［J］.Genet Med,2021,23(11):2087-2095.
［21］ WANG YC,LEE KW,TSAI YS,et al.Downregulation of ATM and brca1 predicts poor outcome in head and neck cancer:implications for ATM-targeted therapy ［J］.J Pers Med,2021,11(5):389.
［22］ YUE LL,WANG FC,ZHANG ML,et al.Association of ATM and bmi-1 genetic variation with breast cancer risk in Han Chinese ［J］.J Cell Mol Med,2018,22(7):3671-3678.
［23］ WANG HC,CHANG WS,TSAI RY,et al.Association between ataxia telangiectasia mutated gene polymorphisms and breast cancer in Taiwanese females ［J］.Anticancer Res,2010,30(12):5217-5221.
［24］ 崔美玲.内蒙古地区散发性乳腺癌与ATM基因多态性的相关性研究［D］.内蒙古:内蒙古医科大学,2020. CUI ML.Correlation between sporadic breast cancer and ATM gene polymorphism in Inner Mongolia ［D］.Inner Mongolia:Inner Mongolia Medical University,2020.
［25］ AMANATULLAH DF,TAMARESIS JS,CHU P,et al.Local estrogen axis in the human bone microenvironment regulates estrogen receptor-positive breast cancer cells ［J］.Breast Cancer Res,2017,19(1):121.
［26］ HU T,CHEN Y,LIU Y,et al.Classification of PR-positive and PR-negative subtypes in ER-positive and HER2-negative breast cancers based on pathway scores［J］.BMC Med Res Methodol,2021,21(1):108.

Memo

Memo:
广西卫计委课题（编号：Z20200008）
Last Update: 1900-01-01