|Table of Contents|

Expression and clinical significance of CRABP2,FABP5,RARγ and PPARβ/δ in esophageal squamous cell carcinoma tissues

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 08
Page:
1448-1455
Research Field:
Publishing date:

Info

Title:
Expression and clinical significance of CRABP2,FABP5,RARγ and PPARβ/δ in esophageal squamous cell carcinoma tissues
Author(s):
LI Mengyan12HOU Guosheng3GAO Yongmei1DAI Litao4WANG Bo1MA Yuqing1
1.Department of Pathology,First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Xinjiang Urumqi 830011,China;2.Department of Pathology;4.Department of Surgery,Changji Jewel Flower Hospital,Xinjiang Fukang 831511,China;3.Department of Pathology,Urumqi Friendship Hospital,Xinjiang Urumqi 830002,China.
Keywords:
esophageal squamous cell carcinomaCRABP2FABP5prognosis
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2023.08.011
Abstract:
Objective:To investigate at the expression and clinical significance of CRABP2,FABP5,RARγ,and PPARβ/δ in esophageal squamous cell carcinoma (ESCC).Methods:In 172 ESCC patients and paired normal tissues,CRABP2,FABP5,RARγ,and PPARβ/δ expression were identified employing immunohistochemical staining.Statistical methods were used to analyze the relation between proteins expression,clinical pathological characteristics and assess prognostic value.Results:There was no link between low expression of CRABP2 and ESCC clinicopathological characteristics.High expression of FABP5 was related with lymph node metastases (P=0.032),depth of infiltration (P=0.041),AJCC staging (P=0.013).The expression of CRABP2 was positively correlated with the expression of FABP5 (r=0.156,P=0.041).The overall survival of patients with high expression of CRABP2 was longer(P=0.025),CRABP2 could be used as an independent prognostic factor for assessing OS in patients with ESCC.FABP5 is an independent prognostic factor used to assess PFS in ESCC patients.Conclusion:CRABP2 and FABP5 might be new therapeutic targets for ESCC.

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Memo

Memo:
新疆维吾尔自治区省部共建中亚高发病成因与防治国家重点实验室面上项目(编号:SKL-HIDCA-2021-27,SKL-HIDCA-2022-10);新疆维吾尔自治区自然科学基金面上项目(编号:2021D01A12)
Last Update: 1900-01-01