|Table of Contents|

Considerations and experiences of the treatment of neuroendocrine neoplasms with integrated traditional Chinese and Western medicine

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 07
Page:
1340-1343
Research Field:
Publishing date:

Info

Title:
Considerations and experiences of the treatment of neuroendocrine neoplasms with integrated traditional Chinese and Western medicine
Author(s):
CHEN Yingying12CHENG Zixuan12TAN Huangying2
1.Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China;2.Department of Integrative Oncology,China-Japan Friendship Hospital,Beijing 100029,China.
Keywords:
neuroendocrine neoplasmsintegrated traditional Chinese and Western medicinetreatmentsthoughts
PACS:
R739.4
DOI:
10.3969/j.issn.1672-4992.2023.07.032
Abstract:
Neuroendocrine neoplasms (NENs) are a group of rare tumors that spread throughout the body with strong heterogeneity,but are commonly observed in the digestive tract and pancreas.Among them,well-differentiated neuroendocrine tumors can show relatively good survival prognosis,while some tumors have malignant biological behaviors,resulting in high mortality,and overall efficacy is still unsatisfactory.The author has been focusing on the diagnosis and treatment of neuroendocrine tumors for many years,keeping up with the research frontiers at home and abroad.At the same time,we explored the treatments of integrated traditional Chinese and Western medicine in different sites of neuroendocrine tumors and various entry points such as well-differentiated and poor-differentiated tumors.The author believes that "benefiting qi,strengthening spleen and harmonizing stomach" should be considered throughout the entire process of neuroendocrine tumor treatment.At the same time,it is necessary to pay attention to soothing the liver and regulating qi,emphasizing the "harmonization of the liver and spleen".In addition,treatments according to combination of diseases differentiation and syndromes differentiation can provide patients with individualized treatments,which can lead a good clinical effectiveness.

References:

[1]陈洁,聂勇战,吴文铭,等.中国肿瘤整合诊治指南·神经内分泌肿瘤[M].天津:天津科学技术出版社,2022:351-352. CHEN J,NIE YZ,WU WM,et al.CACA guidelines for holistic integrative management of cancer.Neuroendocrine neoplasm[M].Tianjin:Tianjin Science and Technology Press,2022:351-352.
[2]DASARI A,SHEN C,HALPERIN D,et al.Trends in the incidence,prevalence,and survival outcomes in patients with neuroendocrine tumors in the United States [J].JAMA Oncol,2017,3(10):1335-1342.
[3]WHO Classification of Tumours Editorial Board.Digestive system tumours(5thed).WHO classification of tumours [M].Geneva:WHO,2019:16-19.
[4]窦豆,邱旭东,陈莹莹,等.“疏木六君子汤”加减治疗1型胃神经内分泌肿瘤的临床观察[J].临床肿瘤学杂志,2019,24(09):824-827. DOU D,QIU XD,CHEN YY,et al.The clinical observation of modified ShumuLiujunzi Decoction for type 1 gastric neuroendocrine neoplasm[J].Chinese Clinical Oncology,2019,24(09):824-827.
[5]张盼.中药预防高分化胰腺神经内分泌肿瘤根治术后复发的临床研究[D].北京中医药大学,2017. ZHANG P.Clinical study of traditional Chinese medicine in preventing recurrence of well-differentiated pancreatic neuroendocrine tumor after radical resection[D].Beijing University of Chinese Medicine,2017.
[6]李梅,窦豆,罗杰,等.中药联合生长抑素类似物治疗晚期胃肠胰腺神经内分泌肿瘤的疗效分析[J].临床肿瘤学杂志,2017,22(03):238-242. LI M,DOU D,LUO J,et al.Clinical observation on traditional Chinese medicine in combination with somatostatin analogues for advanced gastroenteropancreatic neuroendocrine tumors[J].Chinese Clinical Oncology,2017,22(03):238-242.
[7]焦培培,祁志荣,李远良,等.生长抑素类似物配合中药治疗68例晚期胃肠胰神经内分泌肿瘤的疗效观察[J].中日友好医院学报,2022,36(02):92-94. JIAO PP,QI ZR,LI YL,et al.Clinical observation on somatostatin analogues in combination with traditional Chinese medicine for 68 patients with advanced gastroenteropancreatic neuroendocrine tumors[J].Journal of China-Japan Friendship Hospital,2022,36(02):92-94.
[8]DELLE FG,O' TOOLE D,SUNDIN A,et al.ENETS consensus guidelines update for gastroduodenal neuroendocrine neoplasms [J].Neuroendocrinology,2016,103(2):119-124.
[9]ESPOSITO G,CAZZATO M,RINZIVILLO M,et al.Management of type-I gastric neuroendocrine neoplasms:A 10-years prospective single centre study [J].Dig Liver Dis,2021,54(7):890-895.
[10]ROSSI RE,INVERNIZZI P,MAZZAFERRO V,et al.Response and relapse rates after treatment with long-acting somatostatin analogs in multifocal or recurrent type-1 gastric carcinoids:A systematic review and meta-analysis [J].United European Gastroenterol J,2020,8(2):140-147.
[11]李远良,谭煌英.生长抑素类似物在1型胃神经内分泌肿瘤中的治疗进展[J].中日友好医院学报,2017,31(03):187-189. LI YL,TAN HY.Advances in the treatment of somatostatin analogues in type 1 gastric neuroendocrine tumors[J].Journal of China-Japan Friendship Hospital,2017,31(03):187-189.
[12]IDA H,HONMA Y,HIRANO H,et al.Clinical outcomes of patients with G1/G2 neuroendocrine tumors arising from foregut or hindgut treated with somatostatin analogs:a retrospective study[J].Invest New Drugs,2019,37(3):573-578.
[13]BORBATH I,PAPE UF,DEPREZ PH,et al.ENETS standardized (synoptic) reporting for endoscopy in neuroendocrine tumors[J].J Neuroendocrinol,2022,34(3):e13105.
[14]陈莹莹.中药“疏木六君子汤”加减治疗1型胃神经内分泌肿瘤的临床对照观察[D].北京中医药大学,2020. CHEN YY.A clinical controlled observation of Chinese Herbal Decoction (ShumuLiujunzi) for type 1 gastric neuroendocrine tumors[D].Beijing University of Chinese Medicine,2020.
[15]CHEN YY,HAN D,ZHU JQ,et al.A prospective and retrospective clinical controlled observation of Chinese herbal decoction (SMLJ01) for type 1 gastric neuroendocrine tumors [J].Integr Cancer Ther,2020,19:1534735420958488.
[16]NOH JH,KIM DH,YOON H,et al.Clinical outcomes of endoscopic treatment for type 1 gastric neuroendocrine tumor[J].J Gastrointest Surg,2021,25(10):2495-2502.
[17]韩登,李远良,陈莹莹,等.浅谈谭煌英教授中西医结合治疗1型胃神经内分泌肿瘤的临床经验[J].癌症进展,2021,19(19):1961-1963. HAN D,LI YL,CHEN YY,et al.A brief discussion about the clinical experience of Professor Tan Huangying in the treatment of type 1 gastric neuroendocrine tumor with integrated traditional Chinese and Western medicine[J].Oncology Progress,2021,19(19):1961-1963.
[18]陈莹莹,窦豆,谭煌英.香砂六君子汤加减治疗1型胃神经内分泌肿瘤[J].光明中医,2017,32(22):3318-3320. CHEN YY,DOU D,TAN HY.Treatment for type 1 gastric neuroendocrine tumor with Xiangsha Liujunzi Decoction[J].Guangming Journal of Chinese Medicine,2017,32(22):3318-3320.
[19]FAN JH,ZHANG YQ,SHI SS,et al.A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in China [J].Oncotarget,2017,8(42):71699-71708.
[20]HAN IW,PARK J,PARK EY,et al.Fate of surgical patients with small nonfunctioning pancreatic neuroendocrine tumors:An international study using multi-institutional registries[J].Cancers (Basel),2022,14(4):1038.
[21]SINGH S,CHAN DL,MOODY L,et al.Recurrence in resected gastroenteropancreatic neuroendocrine tumors[J].JAMA Oncol,2018,4(4):583-585.
[22]ROSENBLUM RE,HARRIS CK,BAEG KJ,et al.Predictors of recurrence and survival in patients with surgically resected pancreatic neuroendocrine tumors[J].Pancreas,2020,49(2):249-254.
[23]BARRETT JR,RENDELL V,POKRZYWA C,et al.Adjuvant therapy following resection of gastroenteropancreatic neuroendocrine tumors provides no recurrence or survival benefit [J].J Surg Oncol,2020,121(7):1067-1073.
[24]中国临床肿瘤学会指南工作委员会.中国临床肿瘤学会(CSCO)神经内分泌肿瘤诊疗指南[M].北京:人民卫生出版社,2021:74-75. Chinese Society of Clinical Oncology Guidelines Working Committee.Guidelines of Chinese Society of Clinical Oncology (CSCO) neuroendocrine neoplasms[M].Beijing:People's Medical Publishing House,2021:74-75.
[25]王鑫.中药用于高分化胰腺神经内分泌肿瘤根治术后辅助治疗的临床研究[D].北京中医药大学,2020. WANG X.Clinical study of traditional Chinese medicine for adjuvant therapy after radical resection of well-differentiated pancreatic neuroendocrine tumors[D].Beijing University of Chinese Medicine,2020.
[26]中华医学会消化病学分会胃肠激素与神经内分泌肿瘤学组.胃肠胰神经内分泌肿瘤诊治专家共识(2020·广州)[J].中华消化杂志,2021,41(02):76-87. Gastrointestinal Hormone and Neuroendocrine Neoplasm Group,Chinese Society of Gastroenterology,Chinese Medical Association.Expert consensus on diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasm(2020,Guangzhou)[J].Chinese Journal of Digestion,2021,41(02):76-87.
[27]MAO R,LI K,CAI JQ,et al.Adjuvant chemotherapy versus observation following resection for patients with nonmetastatic poorly differentiated colorectal neuroendocrine carcinomas [J].Ann Surg,2021,274(2):e126-e133.
[28]PELLAT A,WALTER T,AUGUSTIN J,et al.Chemotherapy in resected neuroendocrine carcinomas of the digestive tract:A national study from the French Group of Endocrine Tumours[J].Neuroendocrinology,2020,110(5):404-412.
[29]MOLLAZADEGAN K,WELIN S,CRONA J.Systemic treatment of gastroenteropancreatic neuroendocrine carcinoma[J].Curr Treat Options Oncol,2021,22(8):68.
[30]PAVEL M,BERG K,FALCONI M,et al.Gastroenteropancreatic neuroendocrine neoplasms:ESMO Clinical Practice Guidelines for diagnosis,treatment and follow-up[J].Ann Oncol,2020,31(7):844-860.

Memo

Memo:
国家卫生健康委财政专项基金支持资助(编号:2022-NHLHCRF-LX-02-0110)
Last Update: 2023-02-28