|Table of Contents|

The role of exosomes microRNA in metastasis and drug resistance of melanoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 07
Page:
1336-1339
Research Field:
Publishing date:

Info

Title:
The role of exosomes microRNA in metastasis and drug resistance of melanoma
Author(s):
ZHU ZhixinJIAO YanlinWENG ZongqinZHAO Hailong
Zunyi Medical University,Guizhou Zunyi 563000,China.
Keywords:
exosomesmelanomadrug resistancemetastasismicroRNA
PACS:
R739.5
DOI:
10.3969/j.issn.1672-4992.2023.07.031
Abstract:
The occurrence of metastasis and drug resistance is the main way for melanoma to escape the toxicity of targeted chemotherapy drugs,and it is also the most important factor leading to the failure of clinical targeted therapy and the recurrence of the disease.Exosomes are external vesicles secreted by cells,which contain a variety of bioactive substances such as microRNA (miRNA),mRNA and small molecular proteins,and play an important role in tumor progression and diagnosis.Exogenous miRNA can help melanoma cells cross basement membrane,induce epithelial-mesenchymal transition (EMT),promote the establishment of pre-metastasis microenvironment,and participate in melanoma metastasis.At the same time,during the course of chemotherapy,exosomes miRNA reactivated MAPK/PI3K signaling pathway by entering melanoma cells,which led to drug resistance.Therefore,it is of great significance to explore the function and mechanism of exosomes miRNA in the process of melanoma metastasis and drug resistance to improve the cure rate and prognosis of cancer patients.

References:

[1] MILLER KD,NOGUEIRA L,MARIOTTO AB,et al.Cancer treatment and survivorship statistics,2019[J].CA:A Cancer Journal For Clinicians,2019,69(5):363-385.
[2] HAMID O,COWEY CL,OFFNER M,et al.Efficacy,safety,and tolerability of approved combination BRAF and MEK inhibitor regimens for BRAF-mutant melanoma[J].Cancers (Basel),2019,11(11):1642.
[3] SAGINAL AK,BARSOUK A,ALURU JS,et al.Epidemiology of melanoma[J].Med Sci (Basel),2021,9(4):63.
[4] WANG B,ZHANG W,ZHANG G,et al.Targeting mTOR signaling overcomes acquired resistance to combined BRAF and MEK inhibition in BRAF-mutant melanoma[J].Oncogene,2021,40(37):5590-5599.
[5] HAAS L,ELEWAUT A,GERARD CL,et al.Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma[J].Nat Cancer,2021,2(7):693-708.
[6] JAMAL SME,ALAMODI A,WAHL RU,et al.Melanoma stem cell maintenance and chemo-resistance are mediated by CD133 signal to PI3K-dependent pathways[J].Oncogene,2020,39(32):5468-5478.
[7]CANDIDO S,SALEMI R,PICCININ S,et al.The PIK3CA H1047R mutation confers resistance to BRAF and MEK inhibitors in A375 melanoma cells through the cross-activation of MAPK and PI3K-AKt pathways[J].Pharmaceutics,2022,14(3):590.
[8]ZHAO Y,JIN LJ,ZHANG XY.Exosomal miRNA-205 promotes breast cancer chemoresistance and tumorigenesis through E2F1[J].Aging (Albany NY),2021,13(14):18498-18514.
[9]YU S,ZHOU Y,NIU L,et al.Mesenchymal stem cell-derived exosome miR-342-3p inhibits metastasis and chemo-resistance of breast cancer through regulating ID4[J].Genes Genomics,2022,44(5):539-550.
[10] KIM DH,PARK H,CHOI YJ,et al.Exosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2[J].Cell Death Dis,2021,12(8):747.
[11]WANG H,HUANG H,WANG L,et al.Cancer-associated fibroblasts secreted miR-103a-3p suppresses apoptosis and promotes cisplatin resistance in non-small cell lung cancer[J].Aging (Albany NY),2021,13(10):14456-14468.
[12]XIONG J,HE X,XU Y,et al.MiR-200b is upregulated in plasma-derived exosomes and functions as an oncogene by promoting macrophage M2 polarization in ovarian cancer[J].J Ovarian Res,2021,14(1):74.
[13]LI T,LIN L,LIU Q,et al.Exosomal transfer of miR-429 confers chemoresistance in epithelial ovarian cancer[J].Am J Cancer Res,2021,11(5):2124-2141.
[14]KALLURI R,LEBLEU VS.The biology,function,and biomedical applications of exosomes[J].Science,2020,367(6478):eaau6977.
[15]FABIAN MR,SONENBERG N,FILIPOWICZ W.Regulation of mRNA translation and stability by microRNAs[J].Annu Rev Biochem,2010,79(1):351-379.
[16]WANG Z,LIU Y.MicroRNA-633 enhances melanoma cell proliferation and migration by suppressing KAI1[J].Oncol Lett,2021,21(2):88.
[17]DA CRUZ AT,HUNGER A,DE MELO FHM,et al.MiR-138-5p induces aggressive traits by targeting trp53 expression in murine melanoma cells,and correlates with poor prognosis of melanoma patients[J].Neoplasia,2021,23(8):823-834.
[18]TUPONE MG,D'AGUANNO S,DI MARTILE M,et al.MicroRNA-378a-5p is a novel positive regulator of melanoma progression[J].Oncogenesis,2020,9(2):22.
[19]SAHOO A,SAHOO SK,JOSHI P,et al.MicroRNA-211 loss promotes metabolic vulnerability and BRAF inhibitor sensitivity in melanoma[J].J Invest Dermatol,2019,139(1):167-176.
[20]LEE B,SAHOO A,SAWADA J,et al.MicroRNA-211 modulates the DUSP6-ERK5 signaling axis to promote BRAF(V600E)-driven melanoma growth in vivo and BRAF/MEK inhibitor resistance[J].J Invest Dermatol,2021,141(2):385-394.
[21]GRZYWA TM,KLICKA K,PASKAL W,et al.MiR-410-3p is induced by vemurafenib via ER stress and contributes to resistance to BRAF inhibitor in melanoma[J].Plos One,2020,15(6):e0234707.
[22]MASSAGUE J,GANESH K.Metastasis-initiating cells and ecosystems[J].Cancer Discov,2021,11(4):971-994.
[23]GANESH K,MASSAGUE J.Targeting metastatic cancer[J].Nat Med,2021,27(1):34-44.
[24]PEGTEL DM,GOULD SJ.Exosomes[J].Annu Rev Biochem,2019,88(1):487-514.
[25]MORAD G,CARMAN CV,HAGEDORN EJ,et al.Tumor-derived extracellular vesicles breach the intact blood-brain barrier via transcytosis[J].ACS Nano,2019,13(12):13853-13865.
[26]BANKS WA,SHARMA P,BULLOCK KM,et al.Transport of extracellular vesicles across the blood-brain barrier:brain pharmacokinetics and effects of inflammation[J].Int J Mol Sci,2020,21(12):4407.
[27]WANG P,WU Y,CHEN W,et al.Malignant melanoma-derived exosomes induce endothelial damage and glial activation on a human BBB chip model[J].Biosensors (Basel),2022,12(2):89.
[28]LI J,CHEN J,WANG S,et al.Blockage of transferred exosome-shuttled miR-494 inhibits melanoma growth and metastasis[J].J Cell Physiol,2019,234(9):15763-15774.
[29]JACOB A,PREKERIS R.The regulation of MMP targeting to invadopodia during cancer metastasis[J].Front Cell Dev Biol,2015,3:4.
[30]JABLONSKA TRYPUC A,MATEJCZYK M,ROSOCHACKI S.Matrix metalloproteinases (MMPs),the main extracellular matrix (ECM) enzymes in collagen degradation,as a target for anticancer drugs[J].J Enzyme Inhib Med Chem,2016,31(sup1):177-183.
[31]李豪,马雪辉,段乳侠,等.黑色素瘤细胞外泌体对成纤维细胞侵袭和MMP2、MMP9表达的影响[J].陆军军医大学学报,2020,42(08):822-829. LI H,MA XH,DUAN RX,et al.Effects of melanoma cell exosomes on fibroblast invasion and expression of MMP2 and MMP9 in vitro [J].Journal of Army Medical University,2020,42(08):822-829.
[32]WANG C,WANG Y,CHANG X,et al.Melanoma-derived exosomes endow fibroblasts with an invasive potential via miR-21 target signaling pathway[J].Cancer Manag Res,2020,12:12965-12974.
[33]COX TR.The matrix in cancer[J].Nat Rev Cancer,2021,21(4):217-238.
[34]UNTIVEROS G,DEZI L,GILLETTE M,et al.Normal skin cells increase aggressiveness of cutaneous melanoma by promoting epithelial-to-mesenchymal transition via nodal and wnt activity[J].Int J Mol Sci,2021,22(21):11719.
[35]XIAO DY,BARRY S,KMETZ D,et al.Melanoma cell-derived exosomes promote epithelial-mesenchymal transition in primary melanocytes through paracrine/autocrine signaling in the tumor microenvironment[J].Cancer Letters,2016,376(2):318-327.
[36]LUAN WK,DING YT,XI HL,et al.Exosomal miR-106b-5p derived from melanoma cell promotes primary melanocytes epithelial-mesenchymal transition through targeting EphA4[J].Journal of Experimental & Clinical Cancer Research,2021,40(1):107.
[37]LIU Y,CAO X.Characteristics and significance of the pre-metastatic niche[J].Cancer Cell,2016,30(5):668-681.
[38]PEINADO H,KOVIC MA,LAVOTSHKIN S,et al.Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET (vol 18,pg 883,2012)[J].Nature Medicine,2016,22(12):1502.
[39]SHU S,YANG Y,ALLEN CL,et al.Metabolic reprogramming of stromal fibroblasts by melanoma exosome microRNA favours a pre-metastatic microenvironment[J].Sci Rep,2018,8(1):12905.
[40]GENER LAHAV T,ADLER O,ZAIT Y,et al.Melanoma-derived extracellular vesicles instigate proinflammatory signaling in the metastatic microenvironment[J].Int J Cancer,2019,145(9):2521-2534.
[41]ZHOU X,YAN T,HUANG C,et al.Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway[J].J Exp Clin Cancer Res,2018,37(1):242.
[42] LIU D.Exosomal microRNA-4535 of melanoma stem cells promotes metastasis by inhibiting autophagy pathway[J/OL].Stem Cell Reviews & Reports,2022,3(17):8[2022-02-23].https://link.springer.com/article/10.1007/s12015-022-10358-4.DOI:10.1007/s12015-022-10358-4.
[43]LEE B,SAHOO A,SAWADA J,et al.MicroRNA-211 modulates the DUSP6-ERK5 signaling axis to promote BRAF(V600E)-driven melanoma growth in vivo and BRAF/MEK inhibitor resistance[J].Journal of Investigative Dermatology,2021,141(2):385-394.
[44]FELICETTI F,DE FEO A,COSCIA C,et al.Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma[J].Journal of Translational Medicine,2016,14(1):1-15.
[45]LUNAVAT TR,CHENG L,EINARSDOTTIR BO,et al.BRAF(V600) inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells[J].Proc Natl Acad Sci U S A,2017,114(29):E5930-E5939.
[46]NAJEM A,KRAYEM M,PERDRIX A,et al.New drug combination strategies in melanoma:current status and future directions[J].Anticancer Research,2017,37(11):5941-5953.
[47]ZHAO H,HAN L,JIAN Y,et al.Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis[J].Onco Targets and Therapy,2018,11:8995-9006.

Memo

Memo:
National Natural Science Foundation of China(No.82060503);国家自然科学基金资助项目(编号:82060503);贵州省科技计划项目(编号:黔科合基础-ZK[2022]一般622,黔科合基础[2019]1334号);贵州省卫健委科学技术基金资助项目(编号:gzwjkj2019-1-033);遵义医科大学大学生创新创业训练计划项目(编号:ZYDC2022028,ZYDC2022029)
Last Update: 2023-02-28