|Table of Contents|

Application of NR4A3 and Pan-TRK immunohistochemical staining in differential diagnosis of acinic cell carcinoma and secretory carcinoma of salivary gland

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 07
Page:
1237-1240
Research Field:
Publishing date:

Info

Title:
Application of NR4A3 and Pan-TRK immunohistochemical staining in differential diagnosis of acinic cell carcinoma and secretory carcinoma of salivary gland
Author(s):
ZHANG Xiaohong; LIU Xiaojiang; XUE Mei; CHEN Fangwen; WANG Zhihui; YAO Shaobo
Department of Pathology,Linyi Tumor Hospital,Shandong Linyi 276000,China.
Keywords:
salivary gland; acinic cell carcinoma; secretory carcinoma; NR4A3; Pan-TRK
PACS:
R739.87
DOI:
10.3969/j.issn.1672-4992.2023.07.010
Abstract:
Objective:To investigate the value of NR4A3 and Pan-TRK immunohistochemical staining in differential diagnosis of acinic cell carcinoma(AciCC) and secretory carcinoma of salivary gland(SCSG).Methods:The tumors were collected from March 2010 to January 2021 at our hospital,including 22 acinic cell carcinomas,13 salivary gland secretory carcinomas and 132 other salivary gland tumors.NR4A3 and Pan-TRK immunohistochemistry were attempted for all cases.Results：AciCC(21/22) expressed NR4A3 by IHC,among which 17 cases were focal/diffuse strong,4 cases were moderate and 1 case was negative.None of the SCSGs or other salivary gland tumors displayed any nuclear NR4A3 immunostaining.Pan-TRK immunohistochemistry showed that SCSGs(13/13) were positive and AciCCs(22/22) were negative.NR4A3 IHC had 95.5% sensitivity and 100% specificity for AciCC.Conclusion:NR4A3 is a new marker of AciCC，which may be particularly valuable in the differential diagnostic spectrum of AciCC and SCSG.

References:

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Last Update: 2023-02-28