|Table of Contents|

Clinical and pathological features of 5 cases of uterine inflammatory myofibroblastic tumor

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 03
Page:
493-496
Research Field:
Publishing date:

Info

Title:
Clinical and pathological features of 5 cases of uterine inflammatory myofibroblastic tumor
Author(s):
GUO Xingdan1; LIN Chunhua1; ZHOU Zhijiao2; TANG Mi1; CHEN Min1; SANG Na1; LIU Shiwei1; TAN Ting1; ZOU Qiong2
1.Department of Pathology,Hunan Maternity and Infant Hospital,Hunan Changsha 410028,China;2.Department of Pathology,the Third Xiangya Hospital,Central South University,Hunan Changsha 410003,China.
Keywords:
uterine neoplasm; inflammatory myofibroblastic tumor; ALK; immunohistochemistry; FISH
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2023.03.020
Abstract:
Objective:To explore the clinicopathologic features and differential diagnosis of uterine inflammatory myofibroblastic tumor(UIMT).Methods:Five UIMT cases were analyzed for their clinical and pathologic features,and relevant literature was reviewed.Results:The age of the five patients ranged from 23 to 49 years.The initial diagnosis were considered as uterine smooth muscle tumor.The tumors were intramural or submucosal in location,with a medium or slightly fine texture and a mucus sensation.Histologically,the cases were mainly myxoid pattern.Spindle cells are sparsely arranged in myxoid stroma,and in some areas,dense spindle cells are arranged in bundles,similar to leiomyomas.Atypia of tumor cells were mild,with rare mitoses and infiltration of inflammatory cells.Two tumors had infiltrated the adjacent tissues.All the five tumors were ALK-positive with granular cytoplasmic staining by immunohistochemistry.ALK gene rearrangements were detected by fluorescence in situ hybridization(FISH) in five tumors.No metastases and recurrences were found in the postoperative follow-up.Conclusion:The clinical and pathological features of UIMT overlap with those of smooth muscle tumors and endometrial stromal tumors.It is recommended that the diagnosis of UIMT should be combined with histomorphology,ALK immunohistochemistry and FISH detection to avoid misdiagnosis and missed diagnosis.

References:

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Memo

Memo:
湖南省卫生健康委科研计划项目（编号：202101042125）
Last Update: 2022-12-30