|Table of Contents|

Application value of alkaline phosphatase and lymphocyte ratio in evaluating the survival of hepatocellular carcinoma patients with BCLC grade A-B after TACE

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 03
Page:
485-489
Research Field:
Publishing date:

Info

Title:
Application value of alkaline phosphatase and lymphocyte ratio in evaluating the survival of hepatocellular carcinoma patients with BCLC grade A-B after TACE
Author(s):
ZHU Hanping1; XIE Xushuo2; PENG Liang3; LIANG Zengwei2; ZENG Wenting2; WANG Peng1
1.Department of Traditional Chinese Medicine;2.Department of Infectious Medicine;3.Department of Gastroenterology,the First Affiliated Hospital of Guangzhou Medical University,Guangdong Guangzhou 510120,China.
Keywords:
alkaline phosphatase; lymphocyte; hepatocellular carcinoma; propensity score matching method; Kaplan Meier survival analysis
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2023.03.018
Abstract:
Objective:To investigate the value of alkaline phosphatase and lymphocyte ratio(ALR) in predicting the survival of hepatocellular carcinoma(HCC) patients with BCLC grade A-B after TACE.Methods:Taking the tumor progression or death after TACE as the state variable and neutrophil to lymphocyte ratio,lymphocyte to monocyte ratio,alkaline phosphatase(ALP),lymphocyte count and ALR as the test variables,ROC analysis was carried out.All patients were divided into group A and group B according to the best diagnostic cut-off point of preoperative ALR to predict the tumor progression or death after TACE,the patients in the two groups were paired by propensity score matching method,and the propensity score was estimated by logistic regression,the balance of clinicopathological indexes between the two groups was tested,and the absolute value of standard difference was controlled within 0.10,Kaplan-Meier survival analysis was used to compare the progression free survival(PFS) and overall survival(OS) of HCC patients after TACE between group A and group B.Cox regression analysis was used to evaluate the effect of ALR on PFS and OS of HCC patients after TACE.Results:According to the mean value of ALR,all patients were divided into ALR<5.4×10-7(group A) and ALR≥5.4×10-7(group B),through propensity score matching,a total of 57 pairs of patients in the two groups were successfully matched,before matching,the clinical indicators with significant differences between the two groups were balanced,and the balance of other indicators without significant differences was also significantly improved.Kaplan-Meier survival analysis showed that after matching,the 1-year,2-year and 3-year progression free survival rates in group A were significantly higher than those in group B(60.5%,41.2%,33.6% vs 47.9%,20.9%,20.9%,P＜0.05).The 1-year,2-year and 3-year overall survival rates in group A were significantly higher than those in group B(72.3%,62.4%,55.2% vs 63.5%,51.5%,31.8%,P＜0.05),ALR before and after matching were independent predictors of PFS and OS of HCC patients after TACE.Conclusion:Preoperative ALR level has a high value in predicting the long term survival of HCC patients with BCLC grade A-B after TACE.

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Memo

Memo:
广东省自然科学基金（编号:2018A030313970）；广东省广州市卫生和计划生育科技项目（编号:20192A011014）
Last Update: 2022-12-30