|Table of Contents|

Relationship between endothelial activation and stress index and clinical features and prognosis of patients with primary gastrointestinal lymphoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2025 01
Page:
68-72
Research Field:
Publishing date:

Info

Title:
Relationship between endothelial activation and stress index and clinical features and prognosis of patients with primary gastrointestinal lymphoma
Author(s):
LIU Yifan1; ZHAO Juan1; WANG Lina2; XI Yaming2
1.The First Clinical Medical College of Lanzhou University,Gansu Lanzhou 730000,China;2.Department of Hematology,the First Hospital of Lanzhou University,Gansu Lanzhou 730000,China.
Keywords:
EASIX; primary gastrointestinal lymphoma; clinicalfeature; prognosis
PACS:
R733.4
DOI:
10.3969/j.issn.1672-4992.2025.01.011
Abstract:
Objective:To explore the relationship between endothelial activation and stress index (EASIX) and clinical features and prognosis of patients with primary gastrointestinal lymphoma (PGIL).Methods:The clinical data of 74 patients with PGIL admitted to the First Hospital of Lanzhou University from January 1,2000 to December 30,2022 were retrospectively analyzed.Receiver operating characteristic (ROC) curve was used to determine the best cut-off value of EASIX.Categorical variables were compared using the chi-square test or Fisher's exact test and expressed as frequencies and percentages.The overall survival (OS) of PGIL patients with EASIX group was analyzed by Kaplan-Meier survival curve and compared by log-rank test.Cox proportional hazards regression model was used for univariate and multivariate analysis of OS.Results:The optimal cut-off value of EASIX was 0.815.Patients with EASIX≤0.815 before treatment were more in Ann Arbor stage I-II (P=0.005),low risk group and low intermediate risk group of IPI score (P=0.006).Before treatment,EASIX>0.815 was more common in male (P=0.047) and non-low risk IPI (P=0.006) patients.Kaplan-Meier survival curves indicated that patients in the high EASIX group had worse OS than those in the low EASIX group.Cox multivariate regression analysis showed that with A symptom (HR=0.495,95%CI:0.260~0.941,P=0.032),IPI score high-intermediate group and high risk group (HR=3.384,95%CI:1.342~8.533,P=0.01) and EASIX>0.815 (HR=2.607,95%CI:1.326~5.124,P=0.005) were independent risk factors for OS in patients with PGIL.Conclusion:High EASIX before treatment is a risk factor for poor prognosis in patients with PGIL and can be used to evaluate the prognosis of patients with PGIL.

References:

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