[1]CROSBIE EJ,KITSON SJ,MCALPINE JN,et al.Endometrial cancer[J].Lancet,2022,399(10333):1412-1428.
[2]BOKHMAN JV.Two pathogenetic types of endometrial carcinoma[J].Gynecologic Oncology,1983,15(1):10-17.
[3]CANCER GENOME ATLAS RESEARCH N,KANDOTH C,SCHULTZ N,et al.Integrated genomic characterization of endometrial carcinoma[J].Nature,2013,497(7447):67-73.
[4]KOMMOSS S,MCCONECHY MK,KOMMOSS F,et al.Final validation of the ProMisE molecular classifier for endometrial carcinoma in a large population-based case series[J].Annals of Oncology,2018,29(5):1180-1188.
[5]STELLOO E,NOUT RA,OSSE EM,et al.Improved risk assessment by integrating molecular and clinicopathological factors in early-stage endometrial cancer-combined analysis of the PORTEC cohorts[J].Clinical Cancer Research,2016,22(16):4215-4224.
[6]VAN WEELDEN WJ,REIJNEN C,KUSTERS-VANDEVELDE HVN,et al.The cutoff for estrogen and progesterone receptor expression in endometrial cancer revisited:a European Network for Individualized Treatment of Endometrial Cancer collaboration study[J].Human Pathology,2021,109:80-91.
[7]TRAVAGLINO A,RAFFONE A,MOLLO A,et al.TCGA molecular subgroups and FIGO grade in endometrial endometrioid carcinoma[J].Archives of Gynecology and Obstetrics,2020,301(5):1117-1125.
[8]REIJNEN C,VREDE SW,EIJKELENBOOM A,et al.Pure and mixed clear cell carcinoma of the endometrium:A molecular and immunohistochemical analysis study[J].Cancer Med,2023,12(11):12365-12376.
[9]LU KH,BROADDUS RR.Endometrial cancer[J].New England Journal of Medicine,2020,383(21):2053-2064.
[10]URICK ME,BELL DW.Clinical actionability of molecular targets in endometrial cancer[J].Nature Reviews Cancer,2019,19(9):510-521.
[11]DECRUZE SB,GREEN JA.Hormone therapy in advanced and recurrent endometrial cancer:a systematic review[J].International Journal of Gynecological Cancer,2007,17(5):964-978.
[12]CARLSON MJ,THIEL KW,LESLIE KK.Past,present,and future of hormonal therapy in recurrent endometrial cancer[J].International Journal of Women's Health,2014,6:429-435.
[13]KISTNER RW.Histological effects of progestins on hyperplasia and carcinoma in situ of the endometrium[J].Cancer,1959,12:1106-1122.
[14]KELLEY RM,BAKER WH.Progestational agents in the treatment of carcinoma of the endometrium[J].New England Journal of Medicine,1961,264:216-222.
[15]STEINER GJ,KISTNER RW,CRAIG JM.Histological effects of progestins on hyperplasia and carcinoma in situ of the endometrium-further observations[J].Metabolism:Clinical and Experimental,1963,14:356-386.
[16]LENTZ SS,BRADY MF,MAJOR FJ,et al.High-dose megestrol acetate in advanced or recurrent endometrial carcinoma:a Gynecologic Oncology Group Study[J].Journal of Clinical Oncology,1996,14(2):357-361.
[17]THIGPEN JT,BRADY MF,ALVAREZ RD,et al.Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma:a dose-response study by the Gynecologic Oncology Group[J].Journal of Clinical Oncology,1999,17(6):1736-1744.
[18]PODRATZ KC,O' BRIEN PC,MALKASIAN GD,et al.Effects of progestational agents in treatment of endometrial carcinoma[J].Obstetrics and Gynecology,1985,66(1):106-110.
[19]MILESHKIN L,EDMONDSON R,O'CONNELL RL,et al.Phase 2 study of anastrozole in recurrent estrogen(ER)/progesterone (PR) positive endometrial cancer:The PARAGON trial-ANZGOG 0903[J].Gynecologic Oncology,2019,154(1):29-37.
[20]LINDEMANN K,MALANDER S,CHRISTENSEN RD,et al.Examestane in advanced or recurrent endometrial carcinoma:a prospective phase Ⅱ study by the Nordic Society of Gynecologic Oncology(NSGO)[J].BMC Cancer,2014,14:68.
[21]CONCIN N,MATIAS-GUIU X,VERGOTE I,et al.ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma[J].International Journal of Gynecological Cancer,2021,31(1):12-39.
[22]VAN WEELDEN WJ,BRETVELD R,ROMANO A,et al.Trends over time in the incidence and use of hormonal therapy in endometrial cancer:a population-based study in the Netherlands[J].International Journal of Gynecological Cancer,2021,31(7):1014-1020.
[23]THIGPEN JT,BLESSING JA,DISAIA PJ,et al.A randomized comparison of doxorubicin alone versus doxorubicin plus cyclophosphamide in the management of advanced or recurrent endometrial carcinoma:A Gynecologic Oncology Group study[J].Journal of Clinical Oncology,1994,12(7):1408-1414.
[24]FLEMING GF,FILIACI VL,BENTLEY RC,et al.Phase Ⅲ randomized trial of doxorubicin+cisplatin versus doxorubicin+24-h paclitaxel+filgrastim in endometrial carcinoma:a Gynecologic Oncology Group study[J].Annals of Oncology,2004,15(8):1173-1178.
[25]ETHIER JL,DESAUTELS DN,AMIR E,et al.Is hormonal therapy effective in advanced endometrial cancer?A systematic review and meta-analysis[J].Gynecologic Oncology,2017,147(1):158-166.
[26]BESTVINA CM,FLEMING GF.Chemotherapy for endometrial cancer in adjuvant and advanced disease settings[J].Oncologist,2016,21(10):1250-1259.
[27]VAN WEELDEN WJ,LALISANG RI,BULTEN J,et al.Impact of hormonal biomarkers on response to hormonal therapy in advanced and recurrent endometrial cancer[J].American Journal of Obstetrics and Gynecology,2021,225(4):407,e401-407,e416.
[28]JAMIESON A,HUVILA J,CHIU D,et al.Grade and estrogen receptor expression identify a subset of no specific molecular profile endometrial carcinomas at a very low risk of disease-specific death[J].Modern Pathology,2023,36(4):100085.
[29]VERMIJ L,JOBSEN JJ,LEON-CASTILLO A,et al.Prognostic refinement of NSMP high-risk endometrial cancers using oestrogen receptor immunohistochemistry[J].British Journal of Cancer,2023,128(7):1360-1368.
[30]周蓉,王益勤,鹿群,等.早期子宫内膜癌保留生育功能治疗专家共识(2022年版)[J].中国妇产科临床杂志,2023,24(02):215-219.
ZHOU R,WANG YY,LU Q,et al.Expert consensus on fertility preservation treatment for early endometrial cancer(2022 Edition)[J].Chinese Journal of Clinical Obstetrics and Gynecology,2023,24(02):215-219.
[31]PIJNENBORG JMA,VAN WEELDEN WJ,REIJNEN C,et al.Redefining the position of hormonal therapy in endometrial cancer in the era of molecular classification[J].Journal of Clinical Oncology,2024,42(1):8-12.
[32]VAN WEELDEN WJ,BIRKENDAHL PB,LALISANG RI,et al.The effect of progestin therapy in advanced and recurrent endometrial cancer:A systematic review and meta-analysis[J].BJOG,2023,130(2):143-152.
[33]KONSTANTINOPOULOS PA,LEE EK,XIONG N,et al.A phase Ⅱ,two-stage study of letrozole and abemaciclib in estrogen receptor-positive recurrent endometrial cancer[J].Journal of Clinical Oncology,2023,41(3):599-608.
[34]SLOMOVITZ BM,JIANG Y,YATES MS,et al.Phase Ⅱ study of everolimus and letrozole in patients with recurrent endometrial carcinoma[J].Journal of Clinical Oncology,2015,33(8):930-936.
[35]SOLIMAN PT,WESTIN SN,IGLESIAS DA,et al.Everolimus,letrozole,and metformin in women with advanced or recurrent endometrioid endometrial cancer:A multi-center,single arm,phase Ⅱ study[J].Clinical Cancer Research,2020,26(3):581-587.
[36]HEUDEL P,FRENEL JS,DALBAN C,et al.Safety and efficacy of the mTOR inhibitor,vistusertib,combined with anastrozole in patients with hormone receptor-positive recurrent or metastatic endometrial cancer:The VICTORIA multicenter,open-label,phase 1/2 randomized clinical trial[J].JAMA Oncol,2022,8(7):1001-1009.
[37]GREEN AK,ZHOU Q,IASONOS A,et al.A phase Ⅱ study of fulvestrant plus abemaciclib in hormone receptor-positive advanced or recurrent endometrial cancer[J/OL].Clinical Cancer Research,2024(2024-11-19)[2024-11-28].https://doi.org/10.1158/1078-0432.CCR-24-1999.
[38]YONEMORI K,BONI V,MIN KG,et al.Imlunestrant,an oral selective estrogen receptor degrader,as monotherapy and combined with abemaciclib,in recurrent/advanced ER-positive endometrioid endometrial cancer:Results from the phase 1a/1b EMBER study[J/OL].Gynecologic Oncology,2024,191:172-181.(2024-10-22)[2024-11-28].https://doi.org/10.1016/j.ygyno.2024.10.006.
[39]COLON-OTERO G,ZANFAGNIN V,HOU X,et al.Phase Ⅱ trial of ribociclib and letrozole in patients with relapsed oestrogen receptor-positive ovarian or endometrial cancers[J].ESMO Open,2020,5(5):e000926.
[40]ENGELSEN IB,STEFANSSON IM,AKSLEN LA,et al.GATA3 expression in estrogen receptor alpha-negative endometrial carcinomas identifies aggressive tumors with high proliferation and poor patient survival[J].American Journal of Obstetrics and Gynecology,2008,199(5):543,e541-547.
[41]SMITH D,STEWART CJR,CLARKE EM,et al.ER and PR expression and survival after endometrial cancer[J].Gynecologic Oncology,2018,148(2):258-266.
[42]PERRONE E,CAPASSO I,DE FELICE F,et al.Back to the future:The impact of oestrogen receptor profile in the era of molecular endometrial cancer classification[J].European Journal of Cancer,2023,186:98-112.
[43]TANGEN IL,WERNER HM,BERG A,et al.Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions[J].European Journal of Cancer,2014,50(17):3003-3010.
[44]ZHOU W,FRANC BL,DEMARTINI WB,et al.Estrogen receptor-targeted PET imaging for breast cancer[J].Radiology,2024,312(2):e240315.
[45]DAGHER C,MANNING-GEIST B,ELLENSON LH,et al.Molecular subtyping in endometrial cancer:A promising strategy to guide fertility preservation[J].Gynecologic Oncology,2023,179:180-187.
[46]CHUNG YS,WOO HY,LEE JY,et al.Mismatch repair status influences response to fertility-sparing treatment of endometrial cancer[J].American Journal of Obstetrics and Gynecology,2021,224(4):370,e371-370,e313.
[47]DA CRUZ PAULA A,DELAIR DF,FERRANDO L,et al.Genetic and molecular subtype heterogeneity in newly diagnosed early- and advanced-stage endometrial cancer[J].Gynecologic Oncology,2021,161(2):535-544.
[48]ALAFRAIDI M,HOANG L,HOWITT BE,et al.The spectrum of oestrogen receptor expression in endometrial carcinomas of no specific molecular profile[J].Histopathology,2024,85(4):660-670.
[49]VREDE SW,VAN WEELDEN WJ,BULTEN J,et al.Hormonal biomarkers remain prognostically relevant within the molecular subgroups in endometrial cancer[J].Gynecologic Oncology,2024,192:15-23.