|Table of Contents|

Research progress of secreted protein acidic and rich in cysteine（SPARC）in tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 10
Page:
1945-1948
Research Field:
Publishing date:

Info

Title:
Research progress of secreted protein acidic and rich in cysteine（SPARC）in tumors
Author(s):
ZHANG Na1; 2; KONG Yingjun1; LIU Hang1; DAI Can1
1.Department of Respiratory Medicine，the First Affiliated Hospital of Harbin Medical University，Heilongjiang Harbin 150001，China;2.Department of Respiratory Medicine，the Fourth People's Hospital of Shenyang，Liaoning Shenyang 110000，China．
Keywords:
SPARC; tumors; extracellular matrix （ECM）; prognosis and treatment
PACS:
R730.23
DOI:
10.3969/j.issn.1672-4992.2024.10.033
Abstract:
SPARC is an important matrix component in the tumor microenvironment.As an important molecule in the process of normal cell malignancy and tumor development,it can regulate the interaction of a variety of tumor-related cytokines and their receptors,and regulate a variety of signal pathways and the expression level of proteolytic enzymes.Since its ability to inhibit and promote tumor progression depends on cell type,tumor stage,etc,it is differentially expressed in many types of tumors,and may become a new biomarker for early tumor diagnosis and a new target for treatment.This article reviews the progress of SPARC in tumor research in recent years.

References:

［1］ MELOUANE A,YOSHIOKA M,KANZAKI M,et al.Sparc,an EPS-induced gene,modulates the extracellular matrix and mitochondrial function via ILK/AMPK pathways in C2C12 cells［J］.Life Sciences,2019,229(15):277-287.
［2］ WONG SL,SUKKAR MB.The SPARC protein:An overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease［J］.British Journal of Pharmacology,2017,174(1):3-14.
［3］ ANDRIANI F,LANDONI E,MENSAH M,et al.Diagnostic role of circulating extracellular matrix-related proteins in non-small cell lung cancer［J］.BMC Cancer,2018,18(1):899-914.
［4］ MA Y,CHEN H,MA H,et al.Prognostic role of secreted protein acidic and rich in cysteine in patients with solid tumors［J］.Saudi Medical Journal,2019,40(8):755-765.
［5］ BRADSHAW AD.Diverse biological functions of the SPARC family of proteins［J］.Int J Biochem Cell Biol,2012,44(3):480-488.
［6］ SAILAJA GS,BHOOPATHI P,GORANTLA B,et al.The secreted protein acidic and rich in cysteine (SPARC) induces endoplasmic reticulum stress leading to autophagy-mediated apoptosis in neuroblastoma［J］.International Journal of Oncology,2013,42(1):188-196.
［7］ FENG J,TANG L.SPARC in tumor pathophysiology and as a potential therapeutic target［J］.Current Pharmaceutical Design,2014,20(39):6182-6190.
［8］ YANG Y,LI G.Retracted:Icariin inhibits proliferation,migration,and invasion of medulloblastoma DAOY cells by regulation of SPARC［J］.Phytotherapy Research,2020,34(3):591-600.
［9］ ROSSET EM,BRADSHAW AD.SPARC/osteonectin in mineralized tissue［J］.Matrix Biology,2016,52-54:78-87.
［10］ WORKMAN G,SAGE EH.Identification of a sequence in the matricellular protein SPARC that interacts with the scavenger receptor stabilin-1［J］.Journal of Cellular Biochemistry,2011,112(4):1003-1008.
［11］ 胡建文,马永琛,陈国卫.富含半胱氨酸的酸性分泌蛋白与巨噬细胞相互作用对肿瘤进展的影响［J］.中国肿瘤生物治疗杂志,2019,26(03):351-354. HU JW,MA YC,CHEN GW.Effects of interactions between cysteine-rich acidic secreted protein and macro-phages on tumor progression ［J］.Chin J Cancer Biother,2019,26(03):351-354.
［12］ VAZ J,ANSARI D,SASOR A,et al.SPARC:A potential prognostic and therapeutic target in pancreatic cancer［J］.Pancreas,2015(44):1024-1035.
［13］ GHANEMI A,YOSHIOKA M,ST-AMAND J.Secreted protein acidic and rich in cysteine as a regeneration factor:beyond the tissue repair［J］.Life,2021,11(1):38-45.
［14］ BAO JM,DANG Q,LIN CJ,et al.SPARC is a key mediator of TGF-β-induced renal cancer metastasis［J］.Journal of Cellular Physiology,2021,236(3):1926-1938.
［15］OKURA Y,IMAO T,MURASHIMA S,et al.Interaction of nerve growth factor β with adiponectin and SPARC oppositely modulates its biological activity［J］.Int J Mol Sci,2019,20(7):1541-1552.
［16］ GORANTLA B,BHOOPATHI P,CHETTY C,et al.Notch signaling regulates tumor-induced angiogenesis in SPARC-overexpressed neuroblastoma［J］.Angiogenesis,2013,16(1):85-100.
［17］ ZENG B,SUN Z,ZHAO Q,et al.SEC23A inhibit melanoma metastatic through secretory PF4 cooperation with SPARC to inhibit MAPK signaling pathway［J］.Int J Biol Sci，2021，17(12):3000-3012.
［18］ THOMAS SL,SCHULTZ CR,MOUZON E,et al.Loss of SPARC in p53-null astrocytes promotes macrophage activation and phagocytosis resulting in decreased tumor size and tumor cell survival［J］.Brain Pathol,2015,25(4):391-400.
［19］ JING Y,JIN Y,WANG Y,et al.SPARC promotes the proliferation and metastasis of oral squamous cell carcinoma by PI3K/AKT/PDGFB/PDGFRβ axis［J］.Journal of Cellular Physiology,2019,234(9):15581-15593.
［20］ ALCARAZ LB,MALLAVIALLE A,MOLLEVI C,et al.SPARC in cancer-associated fibroblasts is an independent poor prognostic factor in non-metastatic triple-negative breast cancer and exhibits pro-tumor activity［J］.Int J Cancer，2023，152(6):1243-1258.
［21］ SHINTAKUYA R,KONDO N,MURAKAMI Y,et al.The high stromal SPARC expression is independently associated with poor survival of patients with resected pancreatic ductal adenocarcinoma treated with adjuvant gemcitabine in combination with S-1 or adjuvant gemcitabine alone［J］.Pancreatology,2018,18(2):191-197.
［22］ FABRIZIO FP,SPARANEO A,FONTANA A,et al.Potential prognostic role of SPARC methylation in non-small-cell lung cancer［J］.Cells,2020,9(6):1523-1545.
［23］ ZHONG C,LIANG Y,WANG Q,et al.Construction and validation of a novel prediction system for detection of overall survival in lung cancer patients［J］.World J Clin Cases，2022，10(18):5984-6000.
［24］ LIU Y,FENG Y,WANG X,et al.SPARC negatively correlates with prognosis after transarterial chemoembolization and facilitates proliferation and metastasis of hepatocellular carcinoma via ERK/MMP signaling pathways［J］.Front Oncol,2020,10:813-826.
［25］YANG X,XIA Y,WANG S,et al.Prognostic value of SPARC in hepatocellular carcinoma:A systematic review and meta-analysis［J］.PLoS One，2022，17(8):e0273317.
［26］ ALAM R,SCHULTZ CR,GOLEMBIESKI WA,et al.PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma［J］.Neuro Oncol,2013,15(4):451-461.
［27］ CHERN YJ,WONG JCT,CHENG GSW,et al.The interaction between SPARC and GRP78 interferes with ER stress signaling and potentiates apoptosis via PERK/eIF2αand IRE1α/XBP-1 in colorectal cancer［J］.Cell Death & Disease,2019,10(7):504-528.
［28］WU X,CHEN Y,ZHU Y,et al.miR-211-5p inhibits the biological behaviors of colorectal cancer via SPARC-related growth factor pathways［J］.J Cancer，2022，13(6):1895-1904.
［29］ KAZAKOVA E,RAKINA M,SUDARSKIKH T,et al.Angiogenesis regulators S100A4,SPARC and SPP1 correlate with macrophage infiltration and are prognostic biomarkers in colon and rectal cancers［J］.Front Oncol，2023，2(21):13.
［30］ AL-BATRAN SE,GEISSLER M,SEUFFERLEIN T,et al.Nab-paclitaxel for metastatic pancreatic cancer:clinical outcomes and potential mechanisms of action［J］.Oncol Res Treat,2014,37(3):128-134.
［31］ GONG L,MAO W,CHEN Q,et al.Analysis of SPARC and TUBB3 as predictors for prognosis in esophageal squamous cell carcinoma receiving nab-paclitaxel plus cisplatin neoadjuvant chemotherapy:a prospective study［J］.Cancer Chemother Pharmacol,2019,83(4):639-647.
［32］ZHANG F,ZHANG Y,DA J,et al.Downregulation of SPARC expression decreases cell migration and invasion involving epithelial-mesenchymal transition through the p-FAK/p-ERK pathway in esophageal squamous cell carcinoma［J］.J Cancer,2020,11(2):414-420.
［33］ NAKAZAWA Y,NAKAZAWA S,KUROZUMI S,et al.The pathological complete response and secreted protein acidic and rich in cysteine expression in patients with breast cancer receiving neoadjuvant nab-paclitaxel chemotherapy［J］.Oncology Letters,2020,19(4):2705-2712.
［34］ COHEN AL,RAY A,BROCKLIN MV,et al.A phase I trial of azacitidine and nanoparticle albumin bound paclitaxel in patients with advanced or metastatic solid tumors［J］.Oncotarget,2016,8(32):52413-52419.

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