|Table of Contents|

Analysis of CENP-A expression and its clinical significance in cervical cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 10
Page:
1882-1886
Research Field:
Publishing date:

Info

Title:
Analysis of CENP-A expression and its clinical significance in cervical cancer
Author(s):
WANG Yulin1; 2; CAO Wenjing2; 3; ZHAI Yuqing2; 4; YUAN Jiangshui2; SONG Weiqing2
1.Department of Pathogenic Biology,School of Basic Medicine,Qingdao University,Shandong Qingdao 266071,China;2.Department of Laboratory Medicine,Qingdao Municipal Hospital,Shandong Qingdao 266011,China;3.Qingdao University,Shandong Qingdao 266011,China;4.Dalian Medical University,Liaoning Dalian 116044,China.
Keywords:
cervical cancer; centromere protein A; immunohistochemistry; bioinformatics analysis
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2024.10.021
Abstract:
Objective：To analyze the expression of centromere protein A (CENP-A) in cervical cancer,its correlation with clinicopathological parameters and its clinical significance.Methods:Gene Expression Profiling Interactive Analysis (GEPIA) database and Human Protein Atlas(HPA) database were used to analyze the expression of CENP-A gene and protein in cervical cancer tissues and adjacent tissues.The expression level of CENP-A protein in cervical cancer tissues and adjacent tissues was detected by immunohistochemistry,and the relationship between CENP-A protein expression and clinicopathological parameters was analyzed.Using the Linked Omics database to explore the co-expressed genes of CENP-A,and further analyze the signal regulatory pathways that CENP-A gene may participate in the development of cervical cancer.Results:The bioinformatics analysis showed that the expression level of CENP-A in cervical cancer tissues was significantly higher than that in the adjacent tissues (P＜0.05),and the expression of CENP-A protein in cervical cancer tissues is higher than that in the adjacent tissues.The results of immunohistochemistry showed that the expression level of CENP-A protein in cervical cancer tissues was higher than that in the adjacent tissues (P＜0.05),and the expression of CENP-A was correlated with tumor stage and degree of invasion.Through gene co-expression analysis,KIF2C,CDC20,FAM72B and other genes were positively correlated with CENP-A expression,while PARM1,ABCA9 and SYNE1 were negatively correlated with CENP-A expression (FDR<0.05).CENP-A gene is involved in cell cycle,DNA replication and other pathways.Conclusion:CENP-A is highly expressed in cervical cancer tissues,which is related to the prognosis,occurrence and development of cervical cancer.

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山东省青岛市临床检验重点专科项目（编号：V市临床重点专科2023Y13）
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