|Table of Contents|

Correlation between baseline HALP score and related inflammatory indicators and the prognosis of patients with advanced clear cell renal cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 10
Page:
1871-1877
Research Field:
Publishing date:

Info

Title:
Correlation between baseline HALP score and related inflammatory indicators and the prognosis of patients with advanced clear cell renal cell carcinoma
Author(s):
XU Ni; LI Xiaojuan; LIAN Yuying
Department of Oncology,the First People's Hospital of Yibin,Sichuan Yibin 644000,China.
Keywords:
clear cell renal cell carcinoma (ccRCC); HALP score; inflammation; prognosis; neutrophil to lymphocyte ratio (NLR)
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2024.10.019
Abstract:
Objective：To explore the relationship between baseline hemoglobin,albumin,lymphocyte and platelet (HALP) score and related inflammatory indicators and the prognosis of patients with advanced clear cell renal cell carcinoma (ccRCC).Methods:A retrospective study was conducted on 111 patients with AJCC stage III or above ccRCC admitted to our hospital from 2010 to 2018.Patient medical records were collected and followed up until June 30,2023.ROC curve analysis was used to calculate the area under the curve (AUC) and optimal cutoff value of HALP scores and related indicators for predicting patient prognosis.Kaplan-Meier method was used to draw survival curves.Log-rank test and Cox regression analysis were used to explore possible factors affecting patient prognosis.Results:The follow-up period was 63 (55,74) months,and the proportion of deaths during the follow-up period was 29.73%(33/111).The overall survival time (OS) and progression-free survival time (PFS) were 51 (41,60) months and 47 (35,56) months,respectively.The 3-year and 5-year overall survival rates of patients were 84.68% and 70.27%,respectively.The 3-year and 5-year progression-free survival rates were 77.48% and 70.27%,respectively.The AUC of HALP score,NLR,PLR,and LMR in predicting prognosis was 0.920,0.865,0.859,and 0.848 with the optimal cutoff values at 48.0,3.05,88.9,and 4.43,respectively.The treatment method (relative to palliative treatment),AJCC stage,HALP score,and NLR were related to the OS of patients,with HR values of 0.034 (surgical treatment),0.058 (immunotherapy),2.196 (AJCC stage IV),12.532 (HALP＜48.0),and 0.264 (NLR<3.05),respectively.Treatment method (relative to palliative treatment),HALP scores,and NLR were related to patient PFS,with HR values of 0.046 (surgical treatment),0.073 (immunotherapy),12.352 (HALP＜48.0),and 0.252 (NLR<3.05),respectively.Conclusion:The prognosis of advanced ccRCC may be related to the body's nutritional,immune,and inflammatory status.HALP score,NLR,and treatment methods are important influencing factors and predictive factors for patient prognosis.

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四川省卫生和计划生育委员会科研项目（编号：21PJ133）
Last Update: 1900-01-01