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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 05

Page:

843-848

Research Field:

Publishing date:

Info

Title:

Improvement of the evaluation method of the correlation between the state of circumferential margin and postoperative survival and prognosis in patients with esophageal squamous cell carcinoma

Author(s):

LI Jinyong¹; SHEN Sining²; LI Zhenfen³

1.Department of Thoracic Surgery,Kaifeng Cancer Hospital，Henan Kaifeng 475003,China;2.Department of Thoracic Surgery,Henan Cancer Hospital,Henan Zhengzhou 450003,China;3.Department of Pathology,Kaifeng Cancer Hospital,Henan Kaifeng 475003,China.

Keywords:

esophageal squamous cell carcinoma; CAP criteria; RCP criteria; circumferential resection margin

PACS:

R735.1

DOI:

10.3969/j.issn.1672-4992.2024.05.011

Abstract:

Objective:To analyze the correlation between the condition of the circumcision margin and postoperative survival prognosis in patients with esophageal squamous cell carcinoma by calculating the optimal cutoff value of the circumcision margin.Methods:This study retrospectively included 200 patients with esophageal squamous cell carcinoma who underwent surgical treatment at our hospital from April 2012 to January 2018.The postoperative pathological results of all patients showed pT3N0M0.By measuring the minimum distance between tumor cells and the vertical edge,and using X-tile software to calculate the optimal cutoff value of the circumcision edge that affects tumor prognosis.We customized the improved ring cutting edge standard based on the optimal cutoff value and conducted chi square tests and comparative analysis with traditional CAP and RCP standards.At the same time,univariate and multivariate COX regression analysis was used to investigate the factors affecting the prognosis of esophageal squamous cell carcinoma.Results:The results calculated using X-tile software showed that the optimal cutoff value for the ring cutting edge is 0.65 mm.Based on this value,we have customized an improved ring margin standard that can distinguish survival differences between different groups(P＜0.05).The chi square test analysis results showed that after adjusting for clinical pathological parameters such as patient age,gender,tumor location,tumor length,tumor differentiation,and postoperative adjuvant therapy,there was no significant difference among the three types of circumcision margin typing.The results of univariate and multivariate COX regression analysis showed that the customized improved circumferential margin standard in this study was an independent risk factor affecting the prognosis of esophageal squamous cell carcinoma in different surgical groups.Conclusion:The CRM status is an independent prognostic factor for the overall survival in ESCC patients,and the improved CRM criteria have better prognostic capability compared to traditional criteria for assessing the prognosis of ESCC patients.

References:

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Last Update: 2024-01-30