|Table of Contents|

Combined detection of serum NY-ESO-1 autoantibody and MMP1 for the diagnosis of esophageal squamous cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 04
Page:
668-671
Research Field:
Publishing date:

Info

Title:
Combined detection of serum NY-ESO-1 autoantibody and MMP1 for the diagnosis of esophageal squamous cell carcinoma
Author(s):
WU Fangcai1; LIN Yiwei2; CHEN Liuyi2; XU Yiwei2
1.Department of Radiation Oncology;2.Department of Clinical Laboratory,Cancer Hospital of Shantou University Medical College,Guangdong Shantou 515041,China.
Keywords:
matrix metalloproteinase-1; NY-ESO-1 autoantibody; esophageal squamous cell carcinoma; diagnosis marker
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2024.04.014
Abstract:
Objective:To evaluate the diagnostic value of the combination of serum matrix metalloproteinase-1 (MMP1) and New York esophageal squamous cell carcinoma 1 (NY-ESO-1) autoantibody in patients with esophageal squamous cell carcinoma(ESCC).Methods:The study included 120 patients with ESCC and 120 normal controls.Serum levels of MMP1 and NY-ESO-1 autoantibody were measured by enzyme-linked immunosorbent assay (ELISA).Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy.Results:The serum levels of MMP1 and NY-ESO-1 autoantibody were significantly higher in ESCC patients than in normal controls［(8.070±5.738)ng/mL vs (4.331±3.137)ng/mL，Z=6.214，P＜0.001；0.463±0.571 vs 0.156±0.086，Z=5.210，P＜0.001］.ROC curves showed when the optimum diagnostic cutoff of MMP1 was 10.586 ng/mL,the area under the ROC curve (AUC) was 0.732 (95%CI:0.671～0.787),with sensitivity of 24.2%,and specificity of 95.0%.Measurement of NY-ESO-1 autoantibody demonstrated an AUC of 0.695 (95%CI：0.632～0.752),with a sensitivity and specificity of 33.0% and 95.0%.The combination of MMP1 and NY-ESO-1 autoantibody showed an AUC of 0.800 (95%CI：0.744～0.849),a sensitivity of 47.5% and a specificity of 95.0%.Conclusion:Serum MMP1 and NY-ESO-1 autoantibody as potential biomarkers might aid the early diagnosis of ESCC.

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