|Table of Contents|

Relationships of IFN-γ expression with the immune levels and prognosis of patients with esophageal cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 04
Page:
659-663
Research Field:
Publishing date:

Info

Title:
Relationships of IFN-γ expression with the immune levels and prognosis of patients with esophageal cancer
Author(s):
HUANG TengHUANG WeiYU DahaiMA JunZHAO DiLU Hong
Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province Hospital of Chinese Medicine,Jiangsu Nanjing 210000,China.
Keywords:
esophageal cancerIFN-γcellular immunityprognosis predictor
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2024.04.012
Abstract:
Objective:To analyze the relationship of IFN-γ expression with the immune levels and prognosis of patients with esophageal cancer.Methods:A total of 40 patients with esophageal cancer were enrolled,and serum IFN-γ levels and the absolute values of CD4+/CD8+ T cells were detected by flow cytometry.Then,the TISIDB database was used in analyzing the effects of IFN-γ on immunoregulatory genes.The relationship between IFN-γ expression level and prognosis in 119 patients with esophageal cancer was statistically analyzed using a Kaplan-Meier curve.Results:A negative correlation was found between IFN-γ expression in serum and CD4+/CD8+ T cells ratio (R2=0.166 2,P=0.009),and IFN-γ expression was positively correlated with the expression of CD274 (rho=0.449,P<0.001) and PDCD1 (rho=0.778,P<0.001).The expression of IFN-γ was elevated in esophageal cancer tissues compared with the normal tissues(P<0.001).The overall survival (OS) of IFN-γ over-expression patients was shorter than those in IFN-γ low-expression group (P=0.008).Conclusion:The expression of IFN-γ was negatively correlated to immune level and might be a novel predictor for the poor prognosis of esophageal cancer patients.

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Memo

Memo:
江苏省中医院科技项目(编号:Y21022,Y22009);江苏省中医药管理局科技项目(编号:YB201815,YB2020009)
Last Update: 1900-01-01