|Table of Contents|

The value of baseline 18F-FDG PET/CT imaging in the distribution,grading and staging of follicular lymphoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 13
Page:
2496-2501
Research Field:
Publishing date:

Info

Title:
The value of baseline 18F-FDG PET/CT imaging in the distribution,grading and staging of follicular lymphoma
Author(s):
ZHANG Huan1; 2; HU Bin1; 3; HE Liu1; 2; GU Cheng1; ZHANG Xiaoming1; ZHENG Lichun1
1.Department of Nuclear Medicine,Tangshan Gongren Hospital,Hebei Tangshan 063000,China；2.Graduate School,North China University of Science and Technology,Hebei Tangshan 063000,China;3.Hebei Medical University,Hebei Shijiazhuang 050000,China.
Keywords:
follicular lymphoma; positron emission tomography/X-ray computed tomography; 18F-fluorodeoxyglucose; staging
PACS:
R733.4
DOI:
10.3969/j.issn.1672-4992.2023.13.023
Abstract:
Objective:To summarize the characteristics of baseline 18F-FDG PET/CT imaging of follicular lymphoma（FL） and to explore the value of different metabolic parameters of baseline 18F-FDG PET/CT imaging in the distribution,grading,and staging of FL.Methods:A retrospective analysis of 56 patients with pathologically confirmed FL who underwent baseline 18F-FDG PET/CT from January 2014 to December 2022 was performed,and the sites,densities,and maximum diameters of the involved lesions on their baseline 18F-FDG PET/CT imaging were summarized and analyzed.The independent samples t-test was applied to compare the relationship between FL low level group (level 1 and 2),high level group (level 3a and 3b) and Ki-67,SUVmax,TBR and Dmax.The differences in SUVmax and TBR between the limited stage group (stage I and II) and the disseminated stage group (stage III and IV) were analyzed.Results:The most common prevalent sites of the highest metabolic lesions on baseline 18F-FDG PET/CT imaging were the abdominal and the neck lymph nodes,which mostly showed multiple hypermetabolic enlarged lymph nodes in the abdomen and the neck with uniform density and some fusion into clusters.The difference in Ki-67 index between high and low level groups was statistically significant (t=4.621,P＜0.05),and the critical value of Ki-67 index was 35% using ROC curve.There were statistically significant differences in SUVmax,TBR between the high and low-level groups (t=2.481,t=2.514,P＜0.05),with ROC curve critical values of 12.3 and 4.7,respectively,and no statistically significant differences in Dmax (t=1.380,P＞0.05).There was no statistically significant difference in SUVmax and TBR between the limited stage group and the disseminated stage group (t=0.534,1.212,P＞0.05).Conclusion:Baseline 18F-FDG PET/CT imaging of FL mostly showed multiple enlarged lymph nodes in the abdomen and neck with homogeneous and fused masses and different degrees of increased metabolic activity.Baseline 18F-FDG PET/CT was effective in assessing the grading of FL patients and accurately stage them,and the higher the metabolic parameters SUVmax and TBR,the higher the grading,but they were not significantly correlated with the staging period.

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Memo

Memo:
河北省省级科技计划基金资助项目（编号：182777145）；河北省唐山市人才资助项目(编号：A202110028）
Last Update: 2023-05-31